Attenuation of Quorum Sensing Mediated Virulence Factors and Biofilm Formation in Pseudomonas Aeruginosa PAO1 by Substituted Chalcones and Flavonols

Flavonoids epitomize structural scaffolds in many biologically active synthetic and natural compounds. They showcase a diverse spectrum of biological activities including anticancer, antidiabetic, antituberculosis, antimalarial, and antibiofilm activities. The antibiofilm activity of a series of new...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-08, Vol.21 (8), p.e202400393-n/a
Main Authors: Benny, Anjitha Theres, Thamim, Masthan, Easwaran, Nalini, Gothandam, Kodiveri Muthukaliannan, Thirumoorthy, Krishnan, Radhakrishnan, Ethiraj Kannatt
Format: Article
Language:English
Subjects:
antibiofilm
Antimalarial activity
antivirulence
Biofilms
Biological activity
Cell surface
chalcones
Diabetes mellitus
Flavonoids
Flavonols
Gene expression
Hydrophobicity
Molecular docking
Pseudomonas aeruginosa
Pyocyanin
Quorum sensing
RhlR protein
Strain analysis
Virulence
Virulence factors
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Summary:Flavonoids epitomize structural scaffolds in many biologically active synthetic and natural compounds. They showcase a diverse spectrum of biological activities including anticancer, antidiabetic, antituberculosis, antimalarial, and antibiofilm activities. The antibiofilm activity of a series of new chalcones and flavonols against clinically significant Pseudomonas aeruginosa PAO1 strain was studied. Antivirulence activities were screened by analysing the effect of compounds on the production of virulence factors like pyocyanin, LasA protease, cell surface hydrophobicity, and rhamnolipid. The best ligands towards the quorum sensing proteins LasR, RhlR, and PqsR were recognised using a molecular docking study. The gene expression in P. aeruginosa after treatment with test compounds was evaluated on quorum sensing genes including rhlA, lasB, and pqsE. The antibiofilm potential of chalcones and flavonols was confirmed by the efficient reduction in the production of virulence factors and downregulation of gene expression.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400393