Molecular mechanisms of diabetic nephropathy: A narrative review

Diabetic nephropathy (DN) is the predominant secondary nephropathy resulting in global end‐stage renal disease. It is attracting significant attention in both domestic and international research due to its widespread occurrence, fast advancement, and limited choices for prevention and treatment. The...

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Published in:Cell biology international 2024-09, Vol.48 (9), p.1240-1253
Main Authors: Sun, Tian, Guo, Yina, Su, Yanting, Shan, Shigang, Qian, Wenbin, Zhang, Feixue, Li, Mengxi, Zhang, Zhenwang
Format: Article
Language:English
Subjects:
Autophagy
cytokines
Diabetes mellitus
diabetic nephropathy
Epigenetics
inflammatory response
Molecular modelling
Nephropathy
novel molecular mechanisms
Oxidative stress
signaling pathway
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Summary:Diabetic nephropathy (DN) is the predominant secondary nephropathy resulting in global end‐stage renal disease. It is attracting significant attention in both domestic and international research due to its widespread occurrence, fast advancement, and limited choices for prevention and treatment. The pathophysiology of this condition is intricate and involves multiple molecular and cellular pathways at various levels. This article provides a concise overview of the molecular processes involved in the development of DN. It discusses various factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, cellular damage, autophagy, and epigenetics. The aim is to offer clinicians a valuable reference for DN's diagnosis, treatment, and intervention.
ISSN:1065-6995
1095-8355
1095-8355
DOI:10.1002/cbin.12212