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Impact of passive ultrasonic irrigation on the outcome of non-surgical root canal treatment: a systematic review and meta-analysis of randomized clinical trials

Objective This systematic review aimed to assess the impact of Passive Ultrasonic Irrigation on the periapical healing rate of primary root canal treatment compared to conventional syringe irrigation. Methods Registered a priori in the PROSPERO database, this review was conducted by two independent...

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Published in:Evidence-based dentistry 2024-12, Vol.25 (4), p.212-213
Main Authors: Gobbo, Leandro Bueno, de Araújo, Lucas Peixoto, Vieira, Walbert de Andrade, de-Jesus-Soares, Adriana, de Almeida, José Flávio Affonso, Ferraz, Caio Cezar Randi
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container_title Evidence-based dentistry
container_volume 25
creator Gobbo, Leandro Bueno
de Araújo, Lucas Peixoto
Vieira, Walbert de Andrade
de-Jesus-Soares, Adriana
de Almeida, José Flávio Affonso
Ferraz, Caio Cezar Randi
description Objective This systematic review aimed to assess the impact of Passive Ultrasonic Irrigation on the periapical healing rate of primary root canal treatment compared to conventional syringe irrigation. Methods Registered a priori in the PROSPERO database, this review was conducted by two independent reviewers who performed an electronic search up to December 2023. The search included databases such as MEDLINE (PubMed), Scopus, Web of Science, Embase, LILACS, and the Cochrane Library, as well as grey literature. We included randomized clinical trials (RCTs) that focused on patients undergoing primary root canal treatments. The study compared intervention groups using PUI with control groups that did not use activation techniques. Periapical healing was assessed over follow-up periods of at least six months, utilizing either periapical radiographs or cone-beam computed tomography. To synthesize the findings, a meta-analysis and trial sequence analysis were conducted, employing the Relative Risk as the measure of effect, with a 95% confidence interval. The GRADE approach was utilized to assess the certainty of the evidence. Results The meta-analysis incorporated three RCTs, involving 474 patients (501 teeth). The analysis revealed that PUI led to a higher rate of periapical healing compared to CSI (Relative Risk: 1.10; 95% Confidence Interval: 1.01-1.21, I² = 0%), with moderate certainty of evidence. Conclusions Despite the limited number of high-quality RCTs, the findings showed a positive impact of PUI on periapical healing rates in primary root canal treatments, in comparison to CSI. Register CRD42021290894.
doi_str_mv 10.1038/s41432-024-01033-3
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Methods Registered a priori in the PROSPERO database, this review was conducted by two independent reviewers who performed an electronic search up to December 2023. The search included databases such as MEDLINE (PubMed), Scopus, Web of Science, Embase, LILACS, and the Cochrane Library, as well as grey literature. We included randomized clinical trials (RCTs) that focused on patients undergoing primary root canal treatments. The study compared intervention groups using PUI with control groups that did not use activation techniques. Periapical healing was assessed over follow-up periods of at least six months, utilizing either periapical radiographs or cone-beam computed tomography. To synthesize the findings, a meta-analysis and trial sequence analysis were conducted, employing the Relative Risk as the measure of effect, with a 95% confidence interval. The GRADE approach was utilized to assess the certainty of the evidence. Results The meta-analysis incorporated three RCTs, involving 474 patients (501 teeth). The analysis revealed that PUI led to a higher rate of periapical healing compared to CSI (Relative Risk: 1.10; 95% Confidence Interval: 1.01-1.21, I² = 0%), with moderate certainty of evidence. Conclusions Despite the limited number of high-quality RCTs, the findings showed a positive impact of PUI on periapical healing rates in primary root canal treatments, in comparison to CSI. 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ispartof Evidence-based dentistry, 2024-12, Vol.25 (4), p.212-213
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source Springer Nature
subjects 692/698/3008/3010
692/700/3032/3123/3119
Clinical trials
Computed tomography
Dentistry
Endodontics
Evidence-Based Dentistry
Humans
Lavage
Medicine
Meta-analysis
Patients
Randomized Controlled Trials as Topic
Root Canal Irrigants - administration & dosage
Root Canal Irrigants - therapeutic use
Root Canal Therapy - methods
Root canals
Sequence analysis
Systematic review
Therapeutic Irrigation - methods
Treatment Outcome
Ultrasonics
title Impact of passive ultrasonic irrigation on the outcome of non-surgical root canal treatment: a systematic review and meta-analysis of randomized clinical trials
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