A Systematic Review on Biochemical Perspectives on Natural Products in Wound Healing: Exploring Phytochemicals in Tissue Repair and Scar Prevention

Wound healing is a critical process in tissue repair following injury, and traditional herbal therapies have long been utilized to facilitate this process. This review delves into the mechanistic understanding of the significant contribution of pharmacologically demonstrated natural products in woun...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2024-10, Vol.21 (10), p.e202400615-n/a
Main Authors: Raza, Ali, Chohan, Tahir Ali, Zaidi, Syeda Huma H., Hai, Abdul, Alzahrani, Abdullah R., Abida, Imran, Mohd, Saleem, Hammad
Format: Article
Language:English
Subjects:
Animals
Biological compounds
Biological Products - chemistry
Biological Products - pharmacology
Chlorogenic acid
Cicatrix - drug therapy
Cicatrix - metabolism
Cicatrix - prevention & control
Clinical trials
Herbal compounds
Humans
Injury prevention
Metabolites
Natural products
Nutrition
Pharmacology
Phenols
Phytochemicals
Phytochemicals - chemistry
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Prevention
Product development
Reviews
Secondary metabolites
Terpenes
Thymol
Tissue repair
Wound healing
Wound Healing - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Wound healing is a critical process in tissue repair following injury, and traditional herbal therapies have long been utilized to facilitate this process. This review delves into the mechanistic understanding of the significant contribution of pharmacologically demonstrated natural products in wound healing. Natural products, often perceived as complex yet safely consumed compared to synthetic chemicals, play a crucial role in enhancing the wound‐healing process. Drawing upon a comprehensive search strategy utilizing databases such as PubMed, Scopus, Web of Science, and Google Scholar, this review synthesizes evidence on the role of natural products in wound healing. While the exact pharmacological mechanisms of secondary metabolites in wound healing remain to be fully elucidated, compounds from alkaloids, phenols, terpenes, and other sources are explored here to delineate their specific roles in wound repair. Each phytochemical group exerts distinct actions in tissue repair, with some displaying multifaceted roles in various pathways, potentially enhancing their therapeutic value, supported by reported safety profiles. Additionally, these compounds exhibit promise in the prevention of keloids and scars. Their potential alongside economic feasibility may propel them towards pharmaceutical product development. Several isolated compounds, including chlorogenic acid, thymol, and eugenol from natural sources, are undergoing investigation in clinical trials, with many reaching advanced stages. This review provides mechanistic insights into the significant role of pharmacologically demonstrated natural products in wound healing processes.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400615