Radiomics score derived from T1-w/T2-w ratio image can predict motor symptom progression in Parkinson’s disease

Objectives To clarify the association between a radiomics score (Rad-score) derived from T1-weighted signal intensity to T2-weighted signal intensity (T1-w/T2-w) ratio images and the progression of motor symptoms in Parkinson’s disease (PD). Materials and methods This retrospective study included pa...

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Bibliographic Details
Published in:European radiology 2024-12, Vol.34 (12), p.7921-7933
Main Authors: Shimozono, Takuya, Shiiba, Takuro, Takano, Kazuki
Format: Article
Language:English
Subjects:
Aged
Datasets
Diagnostic Radiology
Disease Progression
Feature extraction
Female
Human motion
Humans
Imaging
Imaging Informatics and Artificial Intelligence
Internal Medicine
Interventional Radiology
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Movement disorders
Neurodegenerative diseases
Neuroradiology
Parkinson Disease - diagnostic imaging
Parkinson Disease - physiopathology
Parkinson's disease
Radiology
Radiomics
Rank tests
Regression analysis
Retrospective Studies
Signs and symptoms
Training
Ultrasound
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Summary:Objectives To clarify the association between a radiomics score (Rad-score) derived from T1-weighted signal intensity to T2-weighted signal intensity (T1-w/T2-w) ratio images and the progression of motor symptoms in Parkinson’s disease (PD). Materials and methods This retrospective study included patients with PD enrolled in the Parkinson’s Progression Markers Initiative. The Movement Disorders Society-Unified Parkinson’s Disease Rating Scale Part III score ≥ 33 and/or Hoehn and Yahr stage ≥ 3 indicated motor function decline. The Rad-score was constructed using radiomics features extracted from T1-w/T2-w ratio images. The Kaplan-Meier analysis and Cox regression analyses were used to assess the time differences in motor function decline between the high and low Rad-score groups. Results A total of 171 patients with PD were divided into training ( n  = 101, mean age at baseline, 61.6 ± 9.3 years) and testing ( n  = 70, mean age at baseline, 61.6 ± 10 years). The patients in the high Rad-score group had a shorter time to motor function decline than those in the low Rad-score group in the training dataset (log-rank test, p  
ISSN:1432-1084
0938-7994
1432-1084
DOI:10.1007/s00330-024-10886-2