Continuous renal replacement therapy with vitamin E-coated polysulfone hemofilter reduces inflammatory responses in a porcine lipopolysaccharide-treated model

Biological invasions may promote the onset of systemic inflammatory response syndrome in patients eligible for continuous renal replacement therapy (CRRT), leading to poor prognosis. Hence, we aimed to examine the inflammatory reactions in circulation using vitamin E-coated polysulfone hollow fiber...

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Bibliographic Details
Published in:Therapeutic apheresis and dialysis 2024-07
Main Authors: Horikawa, Takumi, Yagi, Kana, Ishikawa, Chika, Atarashi, Machi, Watanabe, Atsushi, Kato, Yoshihisa
Format: Article
Language:English
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Summary:Biological invasions may promote the onset of systemic inflammatory response syndrome in patients eligible for continuous renal replacement therapy (CRRT), leading to poor prognosis. Hence, we aimed to examine the inflammatory reactions in circulation using vitamin E-coated polysulfone hollow fiber membrane (ViLIFE). Lipopolysaccharides were intravenously administered to pigs (2 μg/kg/30 min) to establish an acute inflammation model. Extracorporeal circulation was performed for 6 h in continuous venovenous hemodiafiltration mode using a hemofilter for CRRT filled with a polysulfone hollow fiber membrane or ViLIFE, and the differences in inflammatory reactions were evaluated. The ViLIFE group exhibited low platelet and cytokine levels (p 
ISSN:1744-9979
1744-9987
1744-9987
DOI:10.1111/1744-9987.14183