Non-Hodgkin lymphoma presenting with spinal cord compression: A population-based analysis of the NHL-BFM study group

• Published in: Pediatric blood & cancer 2024-09, Vol.71 (9), p.e31182
• Main Authors: Riquelme, Amambay, Werner, Jana, Zimmermann, Martin, von Mersi, Hannah, Kabíčková, Edita, Ceppi, Francesco, Foerster, Jan, Finger, Jasmin, Müller, Stephanie, Attarbaschi, Andishe, Burkhardt, Birgit, Woessmann, Wilhelm
• Format: Article
• Language: English
• Subjects: Adolescent; Anaplastic large-cell lymphoma; Chemotherapy; Child; Child, Preschool; Children; Compression; Constipation; Female; Follow-Up Studies; Humans; Lymphoma; Lymphoma, Non-Hodgkin - complications; Lymphoma, Non-Hodgkin - epidemiology; Lymphoma, Non-Hodgkin - pathology; Male; Neurological complications; Non-Hodgkin's lymphoma; Paresis; Paresthesia; Patients; Pediatrics; Population studies; Prognosis; Retrospective Studies; Spinal cord; Spinal Cord Compression - etiology; Steroid hormones; Survival Rate
• ISSN: 1545-5009; 1545-5017; 1545-5017
• DOI: 10.1002/pbc.31182

Spinal cord compression is a rare presentation of non-Hodgkin lymphoma (NHL) in children. We aimed to describe the prevalence, histological subtypes, clinical presentation, therapy, and outcome of those children in a population-based cohort. The chemotherapy regimen remained comparable over time. We retrospectively identified all children and adolescents with paresis as initial manifestations of the NHL between January 1990 and December 2020 from the NHL-BFM database. Characteristics, therapy, and outcome data were gathered from the database and patient files. Fifty-seven of 4779 children (1.2%) presented with initial paresis due to spinal cord compression. The median age was 10.3 years (range, 3.1-18.0 years), and 33% were female. Initial symptoms were paresis/weakness (n = 50, 88%), back pain (n = 33, 58%), paresthesia (n = 23, 40%), and bladder dysfunction and/or constipation (n = 22, 39%), persisting for a median of 14 days before diagnosis. Subtype distribution was mature B-NHL (n = 41, 72%), precursor B-lymphoblastic lymphoma (LBL) (n = 12, 21%), anaplastic large cell lymphoma (ALCL) (n = 3, 5%), and T-LBL (n = 1, 2%). Initial emergency therapy included surgery (70%) and/or chemotherapy/steroids (63%). Five-year event-free survival and overall survival (80% ± 5% and 82% ± 5%, respectively) were comparable with all other NHL patients. Neurological symptoms persisted in approximately one-third of surviving patients at the last follow-up. 1.2% of pediatric NHL patients presented with paresis from spinal cord compression mainly due to B-cell lymphomas. Neurological sequelae were observed in one-third of surviving patients.