Cerebellar functional connectivity relates to lower urinary tract function: A 7 Tesla study

Objectives The objective of this study is to explore the functional connectivity (FC) of the cerebellum during the storage phase of micturition, through detecting spontaneous blood‐oxygen‐level dependent signal between the cerebellum and different brain regions using a high‐resolution 7 Tesla magnet...

Full description

Saved in:
Bibliographic Details
Published in:Neurourology and urodynamics 2024-11, Vol.43 (8), p.2147-2156
Main Authors: Mazeaud, Charles, Bernard, Jessica A., Salazar, Betsy H., Su, Johnny, Karmonik, Christof, Khavari, Rose
Format: Article
Language:English
Subjects:
Adult
Bladder
brain
Brain Mapping
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - physiology
Female
Functional magnetic resonance imaging
functional MRI
Humans
Lower Urinary Tract Symptoms - diagnostic imaging
Lower Urinary Tract Symptoms - physiopathology
Magnetic Resonance Imaging
Male
Neural networks
Neural Pathways - diagnostic imaging
Neural Pathways - physiology
Neuroimaging
Neurological diseases
resting state
Sex differences
Statistical analysis
Urinary Bladder - diagnostic imaging
Urinary Bladder - physiology
Urinary tract
Urination
Urination - physiology
Urogenital system
Young Adult
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives The objective of this study is to explore the functional connectivity (FC) of the cerebellum during the storage phase of micturition, through detecting spontaneous blood‐oxygen‐level dependent signal between the cerebellum and different brain regions using a high‐resolution 7 Tesla magnetic resonance imaging (MRI) scanner. Materials and Methods We recruited healthy individuals with no reported history of neurological disease or lower urinary tract (LUT) symptoms. Participants were asked to drink 500 mL of water and then empty their bladders before entering the MRI scanner. They underwent a T1‐weighted anatomical scan, followed by an initial (8 min) empty bladder resting state functional MRI (rs‐fMRI) acquisition. Once subjects felt the desire to void, a second rs‐fMRI scan was obtained, this time with a full bladder state. We established a priori cerebellar regions of interest from the literature to perform seed‐to‐voxel analysis using nonparametric statistics based on the Threshold Free Cluster Enhancement method and utilized a voxel threshold of p 
ISSN:0733-2467
1520-6777
1520-6777
DOI:10.1002/nau.25535