Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica

The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesq...

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Bibliographic Details
Published in:Journal of asian natural products research 2024-12, Vol.26 (12), p.1557-1564
Main Authors: Ye, Xian-Sheng, Lin, Kuan, Leng, Chang-Long, Gui, Yu-Ran, Zhu, Shu-Xiu, Liu, Hui-Ying, Xia, Yi-Yuan, Sun, Bin-Lian, Liu, Wei, Shu, Xi-Ji
Format: Article
Language:English
Subjects:
Acetic acid
AKT protein
Animals
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
anti-inflammatory effect
Asteraceae
Asteraceae - chemistry
Ethyl acetate
Inflammation
Lactones
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Mice
Molecular Structure
NMR
Nuclear magnetic resonance
phytochemicals
Sesquiterpene lactones
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
sesquiterpenoid lactones
spectral analysis
Youngia japonica
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Summary:The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds 3 and 4 distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.
ISSN:1028-6020
1477-2213
1477-2213
DOI:10.1080/10286020.2024.2370401