18 F-FDG Uptake in Pancreatic AL Amyloidosis Associated With Multiple Myeloma

A 60-year-old woman underwent whole-body contrast-enhanced CT because multiple myeloma was suspected. The contrast-enhanced CT showed pancreatic enlargement without main pancreatic duct dilatation and increased peripancreatic fat tissue. 18 F-FDG PET/CT demonstrated diffuse uptake in the enlargement...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-08, Vol.49 (8), p.781
Main Authors: Kaida, Hayato, Chikugo, Takaaki, Tanaka, Hirokazu, Ishii, Kazunari
Format: Article
Language:English
Subjects:
Amyloidosis - diagnostic imaging
Female
Fluorodeoxyglucose F18
Humans
Immunoglobulin Light-chain Amyloidosis - complications
Immunoglobulin Light-chain Amyloidosis - diagnostic imaging
Immunoglobulin Light-chain Amyloidosis - metabolism
Middle Aged
Multiple Myeloma - diagnostic imaging
Multiple Myeloma - metabolism
Pancreas - diagnostic imaging
Pancreas - metabolism
Pancreas - pathology
Positron Emission Tomography Computed Tomography
Tomography, X-Ray Computed
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Summary:A 60-year-old woman underwent whole-body contrast-enhanced CT because multiple myeloma was suspected. The contrast-enhanced CT showed pancreatic enlargement without main pancreatic duct dilatation and increased peripancreatic fat tissue. 18 F-FDG PET/CT demonstrated diffuse uptake in the enlargement of the pancreas, left and right ventricles, and vertebral column. Biopsy and bone marrow aspiration cytology revealed amyloid light-chain amyloidosis associated with multiple myeloma. Chemotherapy was performed; 18 F-FDG uptake in the pancreas then disappeared, and the pancreatic enlargement decreased. When diffuse 18 F-FDG uptake in pancreatic enlargement is observed in multiple myeloma patients, amyloid light-chain amyloidosis should be considered.
ISSN:1536-0229
1536-0229
DOI:10.1097/RLU.0000000000005296