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Impact of Margin Status on Local Recurrence in Patients with Breast Cancer Undergoing Breast-Conserving Surgery After Neoadjuvant Chemotherapy: A Retrospective Multi-Institutional Cohort Study

Background Questions have been raised as to an increased risk of local recurrence with breast-conserving surgery (BCS) post NAC highlighting the uncertainty around optimal margin width in this patient population. We examined the association between margin status and local recurrence-free survival (L...

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Bibliographic Details
Published in:Annals of surgical oncology 2024-10, Vol.31 (10), p.6786-6794
Main Authors: Di Lena, Élise, Iny, Ericka, Wong, Stephanie M., Bassel, Miranda, Shah, Arusa, Basik, Mark, Boileau, Jean-François, Martel, Karyne, Meterissian, Sarkis, Prakash, Ipshita
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Language:English
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Summary:Background Questions have been raised as to an increased risk of local recurrence with breast-conserving surgery (BCS) post NAC highlighting the uncertainty around optimal margin width in this patient population. We examined the association between margin status and local recurrence-free survival (LRFS) in patients who underwent BCS following NAC. Methods We performed a retrospective cohort study of adult female patients with stage I–III breast cancer who underwent NAC followed by BCS between 2012 and 2021 at two cancer centers. Margins were categorized as “close” if they were
ISSN:1068-9265
1534-4681
1534-4681
DOI:10.1245/s10434-024-15716-9