Thoracic SMARCA4-Deficient Undifferentiated Tumor Mimicking Malignant Pleural Mesothelioma on FDG PET/CT

We describe contrast-enhanced CT and FDG PET/CT findings in a case of thoracic SMARCA4-deficient undifferentiated tumor with extensive pleural involvement and mediastinal lymph node metastases. Contrast-enhanced CT showed multiple enhancing right-sided pleural masses and soft tissue plaques and enla...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-10, Vol.49 (10), p.978-980
Main Authors: Wu, Haibo, Zhou, Yinting, Dong, Aisheng, Wang, Yang, Han, Yan
Format: Article
Language:English
Subjects:
Diagnosis, Differential
DNA Helicases - genetics
Fluorodeoxyglucose F18
Humans
Lung Neoplasms - diagnostic imaging
Male
Mesothelioma - diagnostic imaging
Mesothelioma, Malignant - diagnostic imaging
Middle Aged
Multimodal Imaging
Nuclear Proteins - deficiency
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Pleural Neoplasms - diagnostic imaging
Positron Emission Tomography Computed Tomography
Thoracic Neoplasms - diagnostic imaging
Tomography, X-Ray Computed
Transcription Factors - genetics
Citations: Items that this one cites
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Summary:We describe contrast-enhanced CT and FDG PET/CT findings in a case of thoracic SMARCA4-deficient undifferentiated tumor with extensive pleural involvement and mediastinal lymph node metastases. Contrast-enhanced CT showed multiple enhancing right-sided pleural masses and soft tissue plaques and enlarged mediastinal lymph nodes. The pleural lesions and mediastinal lymph nodes showed intense FDG uptake mimicking malignant pleural mesothelioma with mediastinal lymph node metastases.
ISSN:0363-9762
1536-0229
1536-0229
DOI:10.1097/RLU.0000000000005358