The influence of neuropeptide Y (NPY) on the relationship between emotion regulation and mood-related pathology in survivors of childhood interpersonal trauma

Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely expressed throughout the limbic system. Recent evidence has highlighted NPY as a marker of resilience to posttraumatic psychopathology, which may be due to its association with neural regions involved with emotion regulation. This study...

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Bibliographic Details
Published in:Journal of affective disorders 2024-10, Vol.362, p.258-262
Main Authors: Stevens, Sarah K., Boley, Randy, Pollack, Mark, Hobfoll, Stevan, Shankman, Stewart, Pinkerton, Linzy, Valdespino-Hayden, Zerbrina, Glover, Angela C., Kaufman, Michelle, Dowd, Sheila, Zalta, Alyson K.
Format: Article
Language:English
Subjects:
Adult
Adverse Childhood Experiences - psychology
Affect - physiology
Anxiety
Biomarker
Depression
Emotion regulation
Emotional Regulation - physiology
Female
Humans
Interpersonal Relations
Male
Middle Aged
Mood Disorders - blood
Mood Disorders - psychology
Neuropeptide Y - blood
Neuropeptide-Y
Posttraumatic stress
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - psychology
Survivors - psychology
Young Adult
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Summary:Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely expressed throughout the limbic system. Recent evidence has highlighted NPY as a marker of resilience to posttraumatic psychopathology, which may be due to its association with neural regions involved with emotion regulation. This study examined whether plasma NPY levels moderated the relationship between emotion regulation and psychopathology in a sample of adult survivors of childhood interpersonal trauma, a population known to be at high risk for psychopathology. Adults exposed to an interpersonal criterion A trauma during childhood (N = 54) were recruited from an urban population at a midwestern medical center and completed a baseline study visit as part of a larger clinical trial. Participants gave a blood sample in order to assess circulating levels of NPY and answered questions related to emotion regulation and mood-related pathology. Results of a moderated multiple regression showed that the overall model was significant R2 = 0.26, F (5, 48) = 3.46, p 
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.07.009