HIF-1 mediated metabolic reprogramming in cancer: Mechanisms and therapeutic implications

Cancer cells undergo metabolic reprogramming to survive in hypoxic conditions and meet the elevated energy demands of the cancer microenvironment. This metabolic alteration is orchestrated by hypoxia-inducible factor 1 (HIF-1), regulating various processes within cancer cells. The intricate metaboli...

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Bibliographic Details
Published in:Life sciences (1973) 2024-09, Vol.352, p.122890, Article 122890
Main Authors: Taneja, Nikita, Chauhan, Akansha, Kulshreshtha, Ritu, Singh, Sandhya
Format: Article
Language:English
Subjects:
Cancer metabolism
Cancer therapeutics
Hypoxia inducible factor (HIF-1)
Metabolic reprogramming
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Summary:Cancer cells undergo metabolic reprogramming to survive in hypoxic conditions and meet the elevated energy demands of the cancer microenvironment. This metabolic alteration is orchestrated by hypoxia-inducible factor 1 (HIF-1), regulating various processes within cancer cells. The intricate metabolic modifications induced by hypoxia underscore the significance of HIF-1-induced metabolic reprogramming in promoting each aspect of cancer progression. The complex interactions between HIF-1 signalling and cellular metabolic processes in response to hypoxia are examined in this study, focusing on the metabolism of carbohydrates, nucleotides, lipids, and amino acids. Comprehending the various regulatory mechanisms controlled by HIF-1 in cellular metabolism sheds light on the intricate biology of cancer growth and offers useful insights for developing targeted treatments. [Display omitted]
ISSN:0024-3205
1879-0631
1879-0631
DOI:10.1016/j.lfs.2024.122890