Optical discrimination of pathological red blood cells

Fast diagnostic methods are crucial to reduce the burden on healthcare systems. Currently, detection of diabetes complications such as neuropathy requires time‐consuming approaches to observe the correlated red blood cells (RBCs) morphological changes. To tackle this issue, an optical analysis of RB...

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Published in:Biotechnology and bioengineering 2024-10, Vol.121 (10), p.3311-3318
Main Authors: Vergari, Michele, Niccolini, Benedetta, Pitocco, Dario, Rizzi, Alessandro, Ciasca, Gabriele, Spirito, Marco, Gavioli, Luca
Format: Article
Language:English
Subjects:
anomalous diffraction approximation
Deformability
Deformation
Diabetes mellitus
Diabetes Mellitus - blood
Diabetes Mellitus - pathology
Diabetic neuropathy
erythrocyte light scattering
erythrocyte morphology
Erythrocytes
Erythrocytes - cytology
Formability
Humans
Mie scattering
Mie theory
Morphology
Neuropathy
Optical analysis
optical spectrum correlation with patient's health conditions
optical transmission and reflection
Oscillations
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Summary:Fast diagnostic methods are crucial to reduce the burden on healthcare systems. Currently, detection of diabetes complications such as neuropathy requires time‐consuming approaches to observe the correlated red blood cells (RBCs) morphological changes. To tackle this issue, an optical analysis of RBCs in air was conducted in the 250–2500 nm range. The distinct oscillations present in the scattered and direct transmittance spectra have been analyzed with both Mie theory and anomalous diffraction approximation. The results provide information about the swelling at the ends of RBCs and directly relate the optical data to RBCs morphology and deformability. Both models agree on a reduction in the size and deformability of RBCs in diabetic patients, thus opening the way to diabetes diagnosis and disease progression assessment.
ISSN:0006-3592
1097-0290
1097-0290
DOI:10.1002/bit.28798