Mesenchymal stem cells and their potential therapeutic benefits and challenges in the treatment and pathogenesis of gastric cancer

• Published in: Pathology, research and practice research and practice, 2024-08, Vol.260, p.155422, Article 155422
• Main Authors: Mohamed, Asma'a H., Shafie, Alaa, Abdulmonem, Waleed Al, Alzahrani, Hassan Swed, Ashour, Amal Adnan, Hjazi, Ahmed, Jamal, Azfar, Aldreiwish, Allolo D., Kamal, Mohammad Azhar, Ahmad, Fuzail, Khan, Nazia
• Format: Article
• Language: English
• Subjects: Animals; Cell Differentiation; Drug delivery; Gastric cancer; Humans; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells; Stomach Neoplasms - pathology; Stomach Neoplasms - therapy; Targeted therapy; Tumor Microenvironment
• ISSN: 0344-0338; 1618-0631; 1618-0631
• DOI: 10.1016/j.prp.2024.155422

Mesenchymal stem/stromal cells (MSCs) are acknowledged for their remarkable ability to undergo differentiation into various cell types. In addition, they exhibit anti-tumor characteristics, prompting endeavors to modify MSCs for employment in cancer therapies. On the contrary, it is imperative to recognize that MSCs have been extensively linked to pathways that facilitate the advancement of tumors. Numerous research studies have sought to modify MSCs for clinical application; however, the outcomes have been ambiguous, potentially due to the heterogeneity of MSC populations. Furthermore, the conflicting roles of MSCs in suppressing and promoting tumor growth present a challenge to the appropriateness of their use in anti-cancer therapies. Currently, there exists a lack of comprehensive comprehension concerning the anti-tumor and pro-tumor characteristics of MSCs for gastric cancer (GC). This article discusses the influence of MSCs on GC, the underlying mechanisms, the origins of MSCs, and their effects. This review article also elucidates how MSCs exhibit dual characteristics of promoting and inhibiting tumor growth. Hence, it is of utmost importance that clinical inquiries aimed at utilizing MSCs as a therapeutic intervention for cancer consider the potentiality of MSCs to accelerate the progression of GC. It is crucial to exercise caution throughout the process of developing MSC-based cellular therapies to enhance their anti-cancer attributes while simultaneously eliminating their tumor-promoting impacts.