Sex differences in patellar facet shape among healthy and osteoarthritic cohorts

• Published in: Osteoarthritis and cartilage 2024-11, Vol.32 (11), p.1433-1442
• Main Authors: Wilson, Laura A.B., Lynch, Joseph T., Ménard, Jo M., Galvin, Catherine R., Smith, Paul N.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Bone morphology; Case-Control Studies; Female; Humans; Imaging, Three-Dimensional; Knee osteoarthritis; Male; Middle Aged; Osteoarthritis, Knee - diagnostic imaging; Osteoarthritis, Knee - pathology; Patella - diagnostic imaging; Patella - pathology; Patellofemoral joint; Patellofemoral Joint - diagnostic imaging; Patellofemoral Joint - pathology; Sex Characteristics; Sex Factors; Sexual dimorphism; Shape modelling; Tomography, X-Ray Computed
• ISSN: 1063-4584; 1522-9653; 1522-9653
• DOI: 10.1016/j.joca.2024.06.018

Patellofemoral osteoarthritis (OA) may be more common in females than males. Reasons for this are not fully understood, but sex differences in patellar morphology may help explain this phenomenon. We quantified differences in patellar morphology between males and females in healthy and patellofemoral OA populations. A total of 97 (50F, 47M) healthy and 67 (40F, 27M) OA knees were scanned via computed tomography. OA individuals were on a waitlist for total knee replacement. Patella 3D models were segmented and 2D measurements were recorded: patellar width and height, lateral and medial facet width, and surface area. Medial and lateral facet surface topography was mapped using 81 points to describe 3D articular surface shape. Sex and group differences were assessed using Procrustes analysis of variance (ANOVA). Data were ordinated using Principal Component Analysis. Differences in patellar 2D measurements between healthy and OA individuals were smaller than were differences between males and females from healthy and OA groups. Sex and healthy/OA differences were most pronounced for medial facet shape, which featured a posteriorly-curving facet and taller, narrower facet shape in males compared to females. Lateral facet shape variance was higher in OA cohorts compared to healthy groups. Medial and lateral facet shapes showed different patterning of variation by sex and healthy/OA status. Lateral facet shape may be of interest in future models of OA risk in the patellofemoral joint, here showing increased magnitudes of variance associated with increased severity of disease (patellofemoral Kellgren and Lawrence score).