Elastogenesis in Focus: Navigating Elastic Fibers Synthesis for Advanced Dermal Biomaterial Formulation

Elastin, a fibrous extracellular matrix (ECM) protein, is the main component of elastic fibers that are involved in tissues’ elasticity and resilience, enabling them to undergo reversible extensibility and to endure repetitive mechanical stress. After wounding, it is challenging to regenerate elasti...

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Bibliographic Details
Published in:Advanced healthcare materials 2024-10, Vol.13 (27), p.e2400484-n/a
Main Authors: Krymchenko, Roman, Coşar Kutluoğlu, Gizem, Hout, Noor, Manikowski, Dominique, Doberenz, Claudia, Kuppevelt, Toin H., Daamen, Willeke F.
Format: Article
Language:English
Subjects:
Biomaterials
Biomedical materials
Biosynthesis
Chemical synthesis
Elastin
elastogenesis
Extracellular matrix
Fibers
Protein biosynthesis
Proteins
regenerative medicine
wound healing
Wounding
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Summary:Elastin, a fibrous extracellular matrix (ECM) protein, is the main component of elastic fibers that are involved in tissues’ elasticity and resilience, enabling them to undergo reversible extensibility and to endure repetitive mechanical stress. After wounding, it is challenging to regenerate elastic fibers and biomaterials developed thus far have struggled to induce its biosynthesis. This review provides a comprehensive summary of elastic fibers synthesis at the cellular level and its implications for biomaterial formulation, with a particular focus on dermal substitutes. The review delves into the intricate process of elastogenesis by cells and investigates potential triggers for elastogenesis encompassing elastin‐related compounds, ECM components, and other molecules for their potential role in inducing elastin formation. Understanding of the elastogenic processes is essential for developing biomaterials that trigger not only the synthesis of the elastin protein, but also the formation of a functional and branched elastic fiber network. Elastin and elastic fibers are essential components that provide elasticity and resilience to various tissues in the human body, including the skin. The main challenge arises after severe wounding, when elastic fibers need to be regenerated. This review provides a comprehensive summary of potential triggers for elastogenesis that may be further applied in novel dermal biomaterial formulations.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202400484