Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional...

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Published in:Clinical infectious diseases 2024-10, Vol.79 (4), p.1034
Main Authors: Prakash Babu, Senbagavalli, Ezhumalai, Komala, Raghupathy, Kalaivani, Karoly, Meagan, Chinnakali, Palanivel, Gupte, Nikhil, Paradkar, Mandar, Devarajan, Arutselvi, Dhanasekaran, Mythili, Thiruvengadam, Kannan, Dauphinais, Madolyn Rose, Gupte, Akshay N, Shivakumar, Shrivijay Balayogendra, Thangakunam, Balamugesh, Christopher, Devasahayam Jesudas, Viswanathan, Vijay, Mave, Vidya, Gaikwad, Sanjay, Kinikar, Aarti, Kornfeld, Hardy, Horsburgh, C Robert, Chandrasekaran, Padmapriyadarsini, Hochberg, Natasha S, Salgame, Padmini, Gupta, Amita, Roy, Gautam, Ellner, Jerrold, Sinha, Pranay, Sarkar, Sonali
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antitubercular Agents - therapeutic use
Cohort Studies
Female
Humans
India - epidemiology
Male
Middle Aged
Prospective Studies
Risk Factors
Treatment Failure
Treatment Outcome
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - mortality
Young Adult
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Summary:In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes.
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciae367