Early detection of necrosis in low-enhanced pancreatic parenchyma using contrast-enhanced computed tomography was a better predictor of clinical outcomes than pancreatic inflammation: A multicentric cohort study of severe acute pancreatitis

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024-09, Vol.24 (6), p.827-833
• Main Authors: Yamamoto, Tomonori, Horibe, Masayasu, Sanui, Masamitsu, Sasaki, Mitsuhito, Mizobata, Yasumitsu, Esaki, Maiko, Sawano, Hirotaka, Goto, Takashi, Ikeura, Tsukasa, Takeda, Tsuyoshi, Oda, Takuya, Yasuda, Hideto, Namiki, Shin, Miyazaki, Dai, Kitamura, Katsuya, Chiba, Nobutaka, Ozaki, Tetsu, Yamashita, Takahiro, Oshima, Taku, Hirota, Morihisa, Moriya, Takashi, Shirai, Kunihiro, Yamamoto, Satoshi, Kobayashi, Mioko, Saito, Koji, Saito, Shinjiro, Iwasaki, Eisuke, Kanai, Takanori, Mayumi, Toshihiko
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cohort Studies; Contrast Media; Contrast-enhanced computed tomography; Female; Humans; Inflammation - diagnostic imaging; Japan - epidemiology; Low-enhanced pancreatic parenchyma; Male; Middle Aged; Necrosis; Pancreas - diagnostic imaging; Pancreas - pathology; Pancreatic inflammation; Pancreatic necrosis; Pancreatitis - diagnostic imaging; Pancreatitis - mortality; Pancreatitis - pathology; Pancreatitis, Acute Necrotizing - diagnostic imaging; Pancreatitis, Acute Necrotizing - mortality; Pancreatitis, Acute Necrotizing - pathology; Prognosis; Retrospective Studies; Severe acute pancreatitis; Severity of Illness Index; Tomography, X-Ray Computed
• ISSN: 1424-3903; 1424-3911; 1424-3911
• DOI: 10.1016/j.pan.2024.07.001

We aim to assess the early use of contrast-enhanced computed tomography (CECT) of patients with severe acute pancreatitis (SAP) using the computed tomography severity index (CTSI) in prognosis prediction. The CTSI combines quantification of pancreatic and extrapancreatic inflammation with the extent of pancreatic necrosis. Post-hoc retrospective analysis of a large, multicentric database (44 institutions) of SAP patients in Japan. The area under the curve (AUC) of the CTSI for predicting mortality and the odds ratio (OR) of the extent of pancreatic inflammation and necrosis were calculated using multivariable analysis. In total, 1097 patients were included. The AUC of the CTSI for mortality was 0.65 (95 % confidence interval [CI:] [0.59–0.70]; p 50 % in low-enhanced pancreatic parenchyma (LEPP) was independently associated with a significant increase in mortality, with OR 2.04 and 95 % CI 1.01–4.12 (P