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An updated study of the relationship between bacterial infections and women's immune system, focusing on bacterial compositions with successful pregnancy

Genital tract infections can cause a variety of harmful health outcomes, including endometritis, bacterial vaginosis, and pelvic inflammatory disease, in addition to infertility. Anaerobic bacteria, such as Gardnerella vaginalis, Megasphaera spp., and Atopobium vaginae, are more commonly identified...

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Bibliographic Details
Published in:Journal of reproductive immunology 2024-09, Vol.165, p.104283, Article 104283
Main Authors: Saleh, Raed Obaid, Salahdin, Omar Dheyauldeen, Ahmad, Irfan, Bansal, Pooja, Kaur, Harpreet, Deorari, Mahamedha, Hjazi, Ahmed, Abosaoda, Munther Kadhim, Mohammed, Israa Hussein, Jawad, Mohammed Abed
Format: Article
Language:English
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Summary:Genital tract infections can cause a variety of harmful health outcomes, including endometritis, bacterial vaginosis, and pelvic inflammatory disease, in addition to infertility. Anaerobic bacteria, such as Gardnerella vaginalis, Megasphaera spp., and Atopobium vaginae, are more commonly identified in cases of bacterial vaginosis than lactobacilli. It is unknown how the microorganisms that cause pelvic inflammatory diseases and endometritis enter the uterus. Both prospective and retrospective research have connected pelvic inflammatory disorders, chronic endometritis, and bacterial vaginosis to infertility. Similar to bacterial vaginosis, endometritis-related infertility is probably caused by a variety of factors, such as inflammation, immune system recognition of sperm antigens, bacterial toxins, and a higher risk of STDs. Preconception care for symptomatic women may include diagnosing and treating pelvic inflammatory disease, chronic endometritis, and bacterial vaginosis before conception to optimize the results of both natural and assisted reproduction. •Imbalances in the bacteria in the vagina can cause inflammation and harm the vaginal tissue.•BV-related infertility is caused by immunodysregulation, causing inflammation.•BV might cause infertility; addressing this condition could lead to a successful pregnancy.
ISSN:0165-0378
1872-7603
1872-7603
DOI:10.1016/j.jri.2024.104283