Electrochemical hydrocarboxylation of enol derivatives with CO2: access to β-acetoxycarboxylic acids

Electrochemical hydrocarboxylation of enol acetates with CO2 is developed. The disclosed process provides β-acetoxycarboxylic acids in 25–66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO2, which leads mainly to alcohols.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-07, Vol.60 (62), p.8099-8102
Main Authors: Ustyuzhanin, Alexander O, Bityukov, Oleg V, Sokolovskiy, Pavel V, Merkulova, Valentina M, Ilovaisky, Alexey I, Liang-Nian He, Vera A Vil’, Alexander O Terent’ev
Format: Article
Language:English
Subjects:
Acetates
Alcohols
Carbon dioxide
Electrolysis
Ethers
Ketones
Online Access:Get full text
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Description
Summary:Electrochemical hydrocarboxylation of enol acetates with CO2 is developed. The disclosed process provides β-acetoxycarboxylic acids in 25–66% yields, in contrast to the electrolysis of ketones, silyl enol ethers and vinyl tosylates with CO2, which leads mainly to alcohols.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02831g