From Lignin to Value-Added Pharmaceutical Intermediates Based on a Benzylic Oxidation Method with O2

We present a catalytic strategy for converting lignin into various pharmaceutical intermediates based on a highly selective lignin depolymerization method and a green benzylic oxidation method employing O2. Selective depolymerization of lignin first afforded 4-ethylphenol, which then efficiently gen...

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Bibliographic Details
Published in:Organic letters 2024-07, Vol.26 (29), p.6076-6080
Main Authors: Zhang, Heng, Liu, Mengying, Zhang, Zhehui, Zhang, Qiuxin, Li, Hengyu, Sun, Yonghui, Wang, Zhimin, Liu, Shucheng, Sun, Zhuohua, Yan, Xingchen, Pan, Jianming
Format: Article
Language:English
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Summary:We present a catalytic strategy for converting lignin into various pharmaceutical intermediates based on a highly selective lignin depolymerization method and a green benzylic oxidation method employing O2. Selective depolymerization of lignin first afforded 4-ethylphenol, which then efficiently generates several pharmaceutical intermediates with a simple 5-step process, resulting in substantial economic benefits. The study provides an innovative solution for the efficient utilization of lignin and the green acquisition of pharmaceutical intermediates.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c01608