An atlas of causal association between micronutrients and osteoarthritis

This study examines the causal relationships between serum micronutrients and site-specific osteoarthritis (OA) using Mendelian Randomization (MR). This study performed a two-sample MR analysis to explore causal links between 21 micronutrients and 11 OA outcomes. These outcomes encompass overall OA,...

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Published in:Preventive medicine 2024-08, Vol.185, p.108063, Article 108063
Main Authors: Wei, Wenming, Qi, Xin, Cheng, Bolun, He, Dan, Qin, Xiaoyue, Zhang, Na, Zhao, Yijing, Chu, Xiaoge, Shi, Sirong, Cai, Qingqing, Yang, Xuena, Cheng, Shiqiang, Meng, Peilin, Hui, Jingni, Pan, Chuyu, Zhao, Boyue, Liu, Li, Wen, Yan, Liu, Huan, Jia, Yumeng, Zhang, Feng
Format: Article
Language:English
Subjects:
Joint replacements
Mendelian randomization
Micronutrient
Osteoarthritis
Sex differences
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Summary:This study examines the causal relationships between serum micronutrients and site-specific osteoarthritis (OA) using Mendelian Randomization (MR). This study performed a two-sample MR analysis to explore causal links between 21 micronutrients and 11 OA outcomes. These outcomes encompass overall OA, seven site-specific manifestations, and three joint replacement subtypes. Sensitivity analyses using MR methods, such as the weighted median, MR-Egger, and MR-PRESSO, assessed potential horizontal pleiotropy and heterogeneity. Genome-wide association summary statistical data were utilized for both exposure and outcome data, including up to 826,690 participants with 177,517 OA cases. All data was sourced from Genome-wide association studies datasets from 2009 to 2023. In the analysis of associations between 21 micronutrients and 11 OA outcomes, 15 showed Bonferroni-corrected significance (P 
ISSN:0091-7435
1096-0260
1096-0260
DOI:10.1016/j.ypmed.2024.108063