Antithrombotic Therapy in Patients Undergoing Transcatheter Aortic Valve Implantation

Transcatheter aortic valve implantation (TAVI) now represents the mainstay of treatment for severe aortic stenosis. Owing to its exceptional procedural efficacy and safety, TAVI has been extended to include patients at lower surgical risk, thus now encompassing a diverse patient population receiving...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-06, Vol.13 (13), p.3636
Main Authors: Pallante, Francesco, Costa, Francesco, Garcia Ruiz, Victoria, Vizzari, Giampiero, Iannello, Pietro, Teresi, Lucio, Carciotto, Gabriele, Lo Giudice, Stefania, Iuvara, Giustina, Laterra, Giulia, Regueiro, Ander, Giustino, Gennaro, Alonso Briales, Juan Horacio, Hernandez, Jose Maria, Barbanti, Marco, Micari, Antonio, Patanè, Francesco
Format: Article
Language:English
Subjects:
Angioplasty
Anticoagulants
Aortic stenosis
Aspirin
Cardiac arrhythmia
Cardiovascular disease
Coronary vessels
Ischemia
Mortality
Pharmacists
Stroke
Thrombosis
Transient ischemic attack
Vein & artery diseases
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Summary:Transcatheter aortic valve implantation (TAVI) now represents the mainstay of treatment for severe aortic stenosis. Owing to its exceptional procedural efficacy and safety, TAVI has been extended to include patients at lower surgical risk, thus now encompassing a diverse patient population receiving this treatment. Yet, long-term outcomes also depend on optimal medical therapy for secondary vascular prevention, with antithrombotic therapy serving as the cornerstone. Leveraging data from multiple randomized controlled trials, the current guidelines generally recommend single antithrombotic therapy, with either single antiplatelet therapy (SAPT) or oral anticoagulation (OAC) alone in those patients without or with atrial fibrillation, respectively. Yet, individualization of this pattern, as well as specific case uses, may be needed based on individual patient characteristics and concurrent procedures. This review aims to discuss the evidence supporting antithrombotic treatments in patients treated with TAVI, indications for a standardized treatment, as well as specific considerations for an individualized approach to treatment.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13133636