Newborn's neural representation of instrumental and vocal music as revealed by fMRI: A dynamic effective brain connectivity study

• Published in: Human brain mapping 2024-07, Vol.45 (10), p.e26724-n/a
• Main Authors: Loukas, Serafeim, Filippa, Manuela, Almeida, Joana Sa, Boehringer, Andrew S., Tolsa, Cristina Borradori, Barcos‐Munoz, Francisca, Grandjean, Didier M., Ville, Dimitri, Hüppi, Petra S.
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Auditory Perception - physiology; Brain - diagnostic imaging; Brain - physiology; Brain Mapping; Female; Humans; Infant, Newborn; Infant, Premature - physiology; instrumental music; Magnetic Resonance Imaging; Male; Music; music perception; newborns; prematurity; Singing - physiology; vocal music; Voice - physiology
• ISSN: 1065-9471; 1097-0193; 1097-0193
• DOI: 10.1002/hbm.26724

Music is ubiquitous, both in its instrumental and vocal forms. While speech perception at birth has been at the core of an extensive corpus of research, the origins of the ability to discriminate instrumental or vocal melodies is still not well investigated. In previous studies comparing vocal and musical perception, the vocal stimuli were mainly related to speaking, including language, and not to the non‐language singing voice. In the present study, to better compare a melodic instrumental line with the voice, we used singing as a comparison stimulus, to reduce the dissimilarities between the two stimuli as much as possible, separating language perception from vocal musical perception. In the present study, 45 newborns were scanned, 10 full‐term born infants and 35 preterm infants at term‐equivalent age (mean gestational age at test = 40.17 weeks, SD = 0.44) using functional magnetic resonance imaging while listening to five melodies played by a musical instrument (flute) or sung by a female voice. To examine the dynamic task‐based effective connectivity, we employed a psychophysiological interaction of co‐activation patterns (PPI‐CAPs) analysis, using the auditory cortices as seed region, to investigate moment‐to‐moment changes in task‐driven modulation of cortical activity during an fMRI task. Our findings reveal condition‐specific, dynamically occurring patterns of co‐activation (PPI‐CAPs). During the vocal condition, the auditory cortex co‐activates with the sensorimotor and salience networks, while during the instrumental condition, it co‐activates with the visual cortex and the superior frontal cortex. Our results show that the vocal stimulus elicits sensorimotor aspects of the auditory perception and is processed as a more salient stimulus while the instrumental condition activated higher‐order cognitive and visuo‐spatial networks. Common neural signatures for both auditory stimuli were found in the precuneus and posterior cingulate gyrus. Finally, this study adds knowledge on the dynamic brain connectivity underlying the newborns capability of early and specialized auditory processing, highlighting the relevance of dynamic approaches to study brain function in newborn populations. Newborns listened to a vocal or instrumental melody. During the vocal condition, sensorimotor and salience network were activated, while during instrumental condition, visual and superior frontal cortex. Common neural signatures for vocal and instrumental melodies were a