Comparing Two Targeted Biopsy Schemes for Detecting Clinically Significant Prostate Cancer in Magnetic Resonance Index Lesions: Two- to Four-Core versus Saturated Transperineal Targeted Biopsy

• Published in: Cancers 2024-06, Vol.16 (13), p.2306
• Main Authors: Morote, Juan, Paesano, Nahuel, Picola, Natàlia, Miró, Berta, Abascal, José M, Servian, Pol, Trilla, Enrique, Méndez, Olga
• Format: Article
• Language: English
• Subjects: Biopsy; Clinical significance; Lesions; Magnetic resonance imaging; Mapping; Prostate cancer; Statistical analysis
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16132306

Since the optimal scheme for targeted biopsies of magnetic resonance imaging (MRI) suspicious lesions remains unclear, we compare the efficacy of two schemes for these index lesions. A prospective trial was conducted in 1161 men with Prostate Imaging Reporting and Data System v 2.1 3-5 undergoing targeted and 12-core systematic biopsy in four centers between 2021 and 2023. Two- to four-core MRI-transrectal ultrasound fusion-targeted biopsies via the transperineal route were conducted in 900 men in three centers, while a mapping per 0.5 mm core method (saturated scheme) was employed in 261 men biopsied in another center. A propensity-matched 261 paired cases were selected for avoiding confounders other than the targeted biopsy scheme. CsPCa (grade group ≥ 2) was identified in 125 index lesions (41.1%) when the two- to four-core scheme was employed, while in 187 (71.9%) when the saturated biopsy ( < 0.001) was used. Insignificant PCa (iPCa) was detected in 18 and 11.1%, respectively ( = 0.019). Rates of csPCa and iPCa remained similar in systematic biopsies. CsPCa detected only in systematic biopsies were 5 and 1.5%, respectively ( = 0.035) in each group. The saturated scheme for targeted biopsies detected more csPCa and less iPCa than did the two- to four-core scheme in the index lesions. The rate of csPCa detected only in the systematic biopsies decreased when the saturated scheme was employed.