Mild Systemic Inflammation Increases Erythrocyte Fragility

There is growing evidence that inflammation impairs erythrocyte structure and function. We assessed the impact of mild systemic inflammation on erythrocyte fragility in three different settings. In order to investigate causation, erythrocyte osmotic fragility was measured in mice challenged with a l...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-07, Vol.25 (13), p.7027
Main Authors: Stuart, Charlotte M, Jacob, Carmen, Varatharaj, Aravinthan, Howard, Sarah, Chouhan, Joe K, Teeling, Jessica L, Galea, Ian
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Biobanks
Biomarkers - blood
Biomarkers - urine
C-Reactive Protein - metabolism
COVID-19
Erythrocytes - metabolism
Female
Hemoglobin
Hemolysis
Humans
Hypotheses
Inflammation
Inflammation - blood
Inflammation - metabolism
Male
Mice
Middle Aged
Morphology
Neopterin - blood
Neopterin - urine
Neutrophils
Osmotic Fragility
Oxidation
Oxidative stress
Proteins
Retrospective Studies
Salmonella
Sepsis
Toxicity
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Summary:There is growing evidence that inflammation impairs erythrocyte structure and function. We assessed the impact of mild systemic inflammation on erythrocyte fragility in three different settings. In order to investigate causation, erythrocyte osmotic fragility was measured in mice challenged with a live attenuated bacterial strain to induce low-grade systemic inflammation; a significant increase in erythrocyte osmotic fragility was observed. To gather evidence that systemic inflammation is associated with erythrocyte fragility in humans, two observational studies were conducted. First, using a retrospective study design, the relationship between reticulocyte-based surrogate markers of haemolysis and high-sensitivity C-reactive protein was investigated in 9292 healthy participants of the UK Biobank project. Secondly, we prospectively assessed the relationship between systemic inflammation (measured by the urinary neopterin/creatinine ratio) and erythrocyte osmotic fragility in a mixed population (n = 54) of healthy volunteers and individuals with long-term medical conditions. Both human studies were in keeping with a relationship between inflammation and erythrocyte fragility. Taken together, we conclude that mild systemic inflammation increases erythrocyte fragility and may contribute to haemolysis. Further research is needed to assess the molecular underpinnings of this pathway and the clinical implications in inflammatory conditions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25137027