Dose Contribution to the Regional Lymph-Node Metastases and Point B from Intracavity and Interstitial Hybrid Brachytherapy in Locally Advanced Cervical Cancer

Analyzing dose distributions to regional lymph-node metastases (RLNMs) in locally advanced cervical cancer (LACC) patients undergoing intracavitary and interstitial hybrid brachytherapy (IC/IS). Dose distributions of eleven LACC patients with 38 RLNMs, and who received 38 IC/IS sessions were analyze...

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Bibliographic Details
Published in:Cancers 2024-06, Vol.16 (13), p.2384
Main Authors: Muramoto, Yoichi, Murakami, Naoya, Okonogi, Noriyuki, Takatsu, Jun, Iijima, Kotaro, Inoue, Tatsuya, Kato, Kanade, Karino, Tatsuki, Kojima, Kanako, Oshima, Masaki, Kosugi, Yasuo, Kawamoto, Terufumi, Hirayama, Takashi, Fujino, Kazunari, Terao, Yasuhisa, Shikama, Naoto
Format: Article
Language:English
Subjects:
Aorta
Bladder
Brachytherapy
Cervical cancer
Cervix
Fistula
Lymph
Lymphatic system
Metastases
Metastasis
Needles
Radiation
Radiation therapy
Rectum
Skull
Ultrasonic imaging
Uterus
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Summary:Analyzing dose distributions to regional lymph-node metastases (RLNMs) in locally advanced cervical cancer (LACC) patients undergoing intracavitary and interstitial hybrid brachytherapy (IC/IS). Dose distributions of eleven LACC patients with 38 RLNMs, and who received 38 IC/IS sessions were analyzed in EQD , considering RLNM positions and ipsilateral interstitial needles; these RLNMs, excepting the para-aortic region, were classified into four groups. RLNMs had a median of two ipsilateral interstitial needles per session. Significant differences were observed in total RLNM D , depending on whether the position was cranial or caudal of the uterine base (85.5 vs. 378.9 cGy, < 0.0001), and whether the RLNM D was associated with a number of ipsilateral interstitial needles between 0-1 or 2 or more (68.4 vs. 112.2 cGy, = 0.006) per session. At each session, Group 1 RLNMs (cranial of the uterine base, 0-1 ipsilateral interstitial needle) had a mean D of 21.1 cGy; Group 2 (cranial, 2 or more), 73.8; Group 3 (caudal, 0-1), 94.7; and Group 4 (caudal, 2 or more), 136.1. RLNMs located caudal of the uterine base associated with two or more ipsilateral interstitial needles in IC/IS had a higher dose contribution, which should be considered when calculating the RLNMs' dose of external beam boost irradiation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16132384