F-actin and heparan sulfate proteoglycan distribution in female mosquito salivary glands and ducts

Directly involved in the “suck-and-spit” physiology, female mosquito salivary glands (SGs) primarily imbibe blood for egg development and release anticoagulants to keep blood flowing. Indirectly involved, mosquitoes can uptake arboviruses during blood feeding from a viremic host.This research examin...

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Bibliographic Details
Published in:Journal of medical entomology 2024-07, Vol.61 (5), p.1214-1221
Main Authors: Bowers, Doria Fassbinder, Ciano, Kristin Ann
Format: Article
Language:English
Subjects:
Actin
Antibodies
Anticoagulants
Aquatic insects
arbovirus
Blood
blood feeding
Contractility
Drinking water
Ducts
Entomology
Exocrine glands
Expulsion
Females
Heparan sulfate
Heparan sulfate proteoglycans
Humidity
Immunohistochemistry
Labeling
Microscopy
Mosquitoes
Physiology
Proteoglycans
Reagents
Salivary gland
Salivary glands
Secretions
Sindbis virus
Sulfates
VECTOR/PATHOGEN/HOST INTERACTION, TRANSMISSION
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Summary:Directly involved in the “suck-and-spit” physiology, female mosquito salivary glands (SGs) primarily imbibe blood for egg development and release anticoagulants to keep blood flowing. Indirectly involved, mosquitoes can uptake arboviruses during blood feeding from a viremic host.This research examined the presence of the filamentous cytoplasmic contractile protein (F-actin) and heparan sulfate proteoglycan (HSPG), in the female mosquito SGs. Immunofluorescent antibody labeling of actin molecules or HSPG combined with anatomy suggests that F-actin forms a network in the SG lobe parenchymal cells attached to intralobar ducts by HSPG. In addition, F-actin twists around intralobar SG ducts in a beaded manner, altogether involved in the expulsion of SG secretions.This arrangement in female Aedes aegypti SGs, suggests that F-actin structures are integrally involved in transmitting infectious agents into hosts.
ISSN:0022-2585
1938-2928
1938-2928
DOI:10.1093/jme/tjae060