Surgical and Oncologic Outcome following Sacrectomy for Primary Malignant Bone Tumors and Locally Recurrent Rectal Cancer

• Published in: Cancers 2024-06, Vol.16 (13), p.2334
• Main Authors: Weidlich, Anne, Schaser, Klaus-Dieter, Weitz, Jürgen, Kirchberg, Johanna, Fritzmann, Johannes, Reeps, Christian, Schwabe, Philipp, Melcher, Ingo, Disch, Alexander, Dragu, Adrian, Winkler, Doreen, Mehnert, Elisabeth, Fritzsche, Hagen
• Format: Article
• Language: English
• Subjects: Bone cancer; Bone tumors; Cancer therapies; Carcinoma; Chemotherapy; Chondrosarcoma; Colorectal cancer; Decision making; Hospitals; Localization; Metastases; Metastasis; Neurological complications; Osteosarcoma; Ostomy; Patients; Pelvis; Radiation therapy; Rectum; Sacrum; Surgery; Survival; Tumors; Veins & arteries; Wound healing; Wound infection
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16132334

Bone sarcoma or direct pelvic carcinoma invasion of the sacrum represent indications for partial or total sacrectomy. The aim was to describe the oncosurgical management and complication profile and to analyze our own outcome results following sacrectomy. In a retrospective analysis, 27 patients (n = 8/10/9 sarcoma/chordoma/locally recurrent rectal cancer (LRRC)) were included. There was total sacrectomy in 9 (incl. combined L5 en bloc spondylectomy in 2), partial in 10 and hemisacrectomy in 8 patients. In 12 patients, resection was navigation-assisted. For reconstruction, an omentoplasty, VRAM-flap or spinopelvic fixation was performed in 20, 10 and 13 patients, respectively. With a median follow-up (FU) of 15 months, the FU rate was 93%. R0-resection was seen in 81.5% (no significant difference using navigation), and 81.5% of patients suffered from one or more minor-to-moderate complications (especially wound-healing disorders/infection). The median overall survival was 70 months. Local recurrence occurred in 20%, while 44% developed metastases and five patients died of disease. Resection of sacral tumors is challenging and associated with a high complication profile. Interdisciplinary cooperation with visceral/vascular and plastic surgery is essential. In chordoma patients, systemic tumor control is favorable compared to LRRC and sarcomas. Navigation offers gain in intraoperative orientation, even if there currently seems to be no oncological benefit. Complete surgical resection offers long-term survival to patients undergoing sacrectomy for a variety of complex diseases.