MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease

Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting a substantial challenge to global public health. The mitochondrial-associated membrane (MAMs) functions as a crucial center for signal transduction an...

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Bibliographic Details
Published in:Neurochemical research 2024-10, Vol.49 (10), p.2682-2698
Main Authors: Luo, Jian-Sheng, Zhai, Wen-Hu, Ding, Ling-Ling, Zhang, Xian-Jie, Han, Jia, Ning, Jia-Qi, Chen, Xue-Meng, Jiang, Wen-Cai, Yan, Ru-Yu, Chen, Meng-Jie
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer's disease
Anesthesiology
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain research
Cell Biology
Cholesterol
Control systems
Dementia
Disease control
Endoplasmic reticulum
Endoplasmic Reticulum - metabolism
Homeostasis
Humans
Hypotheses
Lipids
Mitochondria
Mitochondria - metabolism
Mitochondrial Membranes - metabolism
Molecular modelling
Morphology
Mutation
Nervous system
Neurochemistry
Neurodegenerative diseases
Neurology
Neurosciences
Proteins
Public health
Quality control
Review
Signal quality
Signal transduction
Toxicity
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Summary:Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting a substantial challenge to global public health. The mitochondrial-associated membrane (MAMs) functions as a crucial center for signal transduction and material transport between mitochondria and the endoplasmic reticulum, playing a pivotal role in various pathological mechanisms of AD. The dysregulation of mitochondrial quality control systems is considered a fundamental factor in the development of AD, leading to mitochondrial dysfunction and subsequent neurodegenerative events. Recent studies have emphasized the role of MAMs in regulating mitochondrial quality control. This review will delve into the molecular mechanisms underlying the imbalance in mitochondrial quality control in AD and provide a comprehensive overview of the role of MAMs in regulating mitochondrial quality control.
ISSN:0364-3190
1573-6903
1573-6903
DOI:10.1007/s11064-024-04205-w