Correlation of serum Adenosine Deaminase levels with microbiological parameters in Pulmonary Tuberculosis

Accurate diagnosis of pulmonary tuberculosis is largely based on sputum smear microscopy, culture, and GeneXpert MTB/RIF tests; culture being the gold standard. All these diagnostic tests require sputum sample to be positive for Mycobacterium tuberculosis , while many active TB patients often do not...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2024-07, Vol.39 (3), p.380-386
Main Authors: Sarkar, Krishna, Kashyap, Bineeta, Jhamb, Rajat, Madhu, S. V., Avasthi, Rajnish, Hyanki, Puneeta
Format: Article
Language:English
Subjects:
Adenosine
Adenosine deaminase
Biochemical markers
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Diagnosis
Life Sciences
Microbiology
Microscopy
Original Research Article
Pathology
Sputum
Tuberculosis
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Summary:Accurate diagnosis of pulmonary tuberculosis is largely based on sputum smear microscopy, culture, and GeneXpert MTB/RIF tests; culture being the gold standard. All these diagnostic tests require sputum sample to be positive for Mycobacterium tuberculosis , while many active TB patients often do not present with M. tuberculosis positive sputum. Biochemical markers play an important role in early diagnosis, disease prevention, and drug response in tuberculosis. This study aims to find the association of serum adenosine deaminase (a biomarker) with the various microbiological parameters like sputum smear microscopy, culture and CBNAAT in pulmonary tuberculosis patients. A total of 40 cases were collected from November 2019 to October 2021, and the presumptive cases of pulmonary tuberculosis diagnosed by Ziehl–Neelsen staining for acid fast bacilli and/or CBNAAT were recruited. Serum adenosine deaminase levels were estimated.The following variables were significantly associated ( p  
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-023-01116-5