White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans

Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer's disease in mouse models. However, clinical trials in Alzheimer's disease (AD) patients have yielded inconsistent results, necessitating further investigation. This single-center pre-post...

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Bibliographic Details
Published in:GeroScience 2024-07
Main Authors: Park, Yeseung, Yoon, Euisuk, Park, Jieun, Kim, Jun Sung, Han, Ji Won, Bae, Jong Bin, Kim, Sang-Su, Kim, Do-Won, Woo, Se Joon, Park, Jaehyeok, Lee, Wheesung, Yoo, Seunghyup, Kim, Ki Woong
Format: Article
Language:English
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Summary:Gamma entrainment through sensory stimulation has the potential to reduce the pathology of Alzheimer's disease in mouse models. However, clinical trials in Alzheimer's disease (AD) patients have yielded inconsistent results, necessitating further investigation. This single-center pre-post intervention study aims to explore the influence of white matter microstructural integrity on gamma rhythm propagation from the visual cortex to AD-affected regions in 31 cognitively normal volunteers aged ≥ 65. Gamma rhythm propagation induced by optimal FLS was measured. Diffusion tensor imaging was employed to assess the integrity of white matter tracts of interest. After excluding 5 participants with a deficit in steady-state visually evoked potentials, 26 participants were included in the final analysis. In the linear regression analyses, gamma entrainment was identified as a significant predictor of gamma propagation (p 
ISSN:2509-2723
2509-2723
DOI:10.1007/s11357-024-01281-2