Noninvasive Biomarkers for Alcohol-Related Liver Disease—A Proteomic Related Preliminary Report

Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platele...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of clinical biochemistry 2024-07, Vol.39 (3), p.392-400
Main Authors: Nelaturi, Prabhudas, Kademani, Sangeetha P., Siva Subramanian, Vithiavathi, Ravikumar, Sambandam
Format: Article
Language:English
Subjects:
Alcohol
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Life Sciences
Liquid chromatography
Liver diseases
Mass spectroscopy
Microbiology
Original Research Article
Pathology
Platelets
Proteins
Proteomes
Proteomics
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Increased alcohol intake over decades leads to progressive alcohol-related liver disease (ALD) and contributes to increased mortality. It is characterized by reduced platelet count. Platelets have a role in protecting vascular integrity and involved in liver regeneration. Alcohol affects the platelet count and its function. Platelet function is regulated by their proteins, released during pathophysiological conditions. Therefore, platelet proteome plays a vital role during ALD. This preliminary study consists of 10 patients with ALD. It includes the preparation of human platelets for the proteomic approach. We performed liquid chromatography-mass spectrometry for the samples. A total of 536 proteins were identified in patients with ALD of which 31 proteins were mentioned as a candidate based on their clinical significance. The advancement of diagnostic or therapeutic tools based on the application of platelet proteins in ALD is still far off. Platform for platelet and its proteome research may give diagnostic and prognostic insights into ALD. Platelet proteomes could possibly be concluded as therapeutic and potential diagnostic or prognostic markers in ALD.
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-023-01120-9