A Call for Updates to Hormone Therapy Guidelines for Gender-Diverse Adults Assigned Male at Birth

Gender-affirming hormone therapy for assigned male at birth (AMAB) individuals with gender incongruence typically consists of estradiol with or without an anti-androgen to achieve physical changes and psychological benefits. However, prescribed hormone regimens vary considerably, and high-quality re...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e62262
Main Authors: Patel, Reema, Korenman, Stanley, Weimer, Amy, Grock, Shira
Format: Article
Language:English
Subjects:
Androgens
Bioavailability
Breast cancer
Conversion
Endocrine therapy
Estrogens
Females
Gender-affirming care
Hair loss
Non-binary gender
Patients
Testosterone
Thromboembolism
Transgender persons
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Summary:Gender-affirming hormone therapy for assigned male at birth (AMAB) individuals with gender incongruence typically consists of estradiol with or without an anti-androgen to achieve physical changes and psychological benefits. However, prescribed hormone regimens vary considerably, and high-quality research in this area is extremely limited. Additional evidence-based research evaluating patient-reported outcome measures (PROMs) is needed to fill current knowledge gaps and create a personalized therapeutic approach for AMAB individuals. This editorial provides a critical description of current treatment options, discusses their variability, reviews some discrepancies in guideline-based dosing recommendations, and recommends areas for further study.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62262