Association of interleukin6 rs1800796 gene polymorphism and serum level with bladder cancer in Egyptian population

Background Urinary bladder cancer (UBC)is a common tumor of the urinary tract. Objectives To assess the diagnostic significance of IL6 rs1800796 gene polymorphism and IL6 serum level among Egyptian patients with UBC. Design and methods One hundred patients with UBC were selected from the Mansoura Ur...

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Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.815, Article 815
Main Authors: Mukhlif, Riyad T., Abol-Enein, Hassan, Elsaid, Afaf M., Abdelkhalek, Manar, Khatab, Heba H., Youssef, Magdy M.
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Animal Anatomy
Animal Biochemistry
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biomedical and Life Sciences
Bladder cancer
Case-Control Studies
Egypt - epidemiology
Female
Gene Frequency - genetics
Gene polymorphism
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Histology
Humans
Interleukin-6 - blood
Interleukin-6 - genetics
Life Sciences
Male
Middle Aged
Morphology
Original Article
Polymorphism
Polymorphism, Single Nucleotide - genetics
Urinary bladder
Urinary Bladder Neoplasms - blood
Urinary Bladder Neoplasms - genetics
Urinary tract
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Summary:Background Urinary bladder cancer (UBC)is a common tumor of the urinary tract. Objectives To assess the diagnostic significance of IL6 rs1800796 gene polymorphism and IL6 serum level among Egyptian patients with UBC. Design and methods One hundred patients with UBC were selected from the Mansoura Urology and Nephrology Center, in addition to 100 healthy control subjects; using PCR and ELISA techniques for IL6 detection. Results The rs1800796 GC, CC genotypes, and C allele were significantly more prevalent in the cases with bladder cancer compared to the healthy group ( p  
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-09791-0