The effect of pulmonary rehabilitation on cardiovascular risk, oxidative stress and systemic inflammation in patients with COPD

• Published in: Respiratory medicine 2024-10, Vol.232, p.107740, Article 107740
• Main Authors: Muñoz Montiel, Ana, Ruiz-Esteban, Pedro, Doménech Del Río, Adolfo, Valdivielso, Pedro, Sánchez Chaparro, Miguel Ángel, Olveira, Casilda
• Format: Article
• Language: English
• Subjects: Aged; ApoB48; Cardiovascular Diseases - prevention & control; Cardiovascular risk (CVR); Chronic obstructive pulmonary disease (COPD); Dyslipidemias - complications; Exercise Tolerance - physiology; Female; Forced Expiratory Volume; Heart Disease Risk Factors; Humans; Inflammation; Male; Middle Aged; Oxidative Stress - physiology; Phenotype; Prospective Studies; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - rehabilitation; Pulmonary rehabilitation (PR); Risk Factors; Vital Capacity; Walk Test
• ISSN: 0954-6111; 1532-3064; 1532-3064
• DOI: 10.1016/j.rmed.2024.107740

Chronic obstructive pulmonary disease (COPD) is a leading cause of death, and cardiovascular (CV) comorbidities play a role. Evidence of the pulmonary rehabilitation (PR) effect in reducing the CV risk (CVR) in COPD patients is limited. In this study, we aimed to determine the impact of an 8-week PR program (PRP) on the CVR of the overall population and to compare the impact on the exacerbator versus non-exacerbator patients. This was a prospective study that included adults who had post-bronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) (FEV1/FVC) ratio