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Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant
Introduction This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT). Methods This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacterem...
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| Published in: | Transplant infectious disease 2024-08, Vol.26 (4), p.e14345-n/a |
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| container_issue | 4 |
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| container_title | Transplant infectious disease |
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| creator | Sheu, Michael Molina Garcia, Sofia Shrivastava, Gautam Patel, Meera Mushtaq, Ali Crilley, Thomas Anwer, Faiz Majeed, Aneela |
| description | Introduction
This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT).
Methods
This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
Results
Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
Conclusion
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures was low for detecting previously detected and new pathogens. |
| doi_str_mv | 10.1111/tid.14345 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3081299972</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3090941680</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2435-4b88ccd484e580f2efee0fd2b72f4d0373f519eebd48fe39909e2624b10856bc3</originalsourceid><addsrcrecordid>eNp1kbtuFTEQhlcIRC5Q8ALIEg0Um_i2F5cogRApUpqkoFr5Mk4cvPZie3V0Hoc3xTknpIjENB5L33wazd80Hwg-IbVOizMnhDPevWoOCROiZbinr3f92FI6sIPmKOcHjMkguHjbHDCBCe0JP2z-_HTgDYoWJVhAFqR8jAbp1Zc1QUYuIKnXAmjego_OIA_rL5idRIssDkLJaOPKPbKgkvOAAqwlxQVCJWQwSEldIO0GbPQ-bly4Q7I2dxDAaXQPsyxxiQ5K_eUCM9LgPSpJhrx4Gcq75o2VPsP7p_e4uf3-7ebsR3t1fXF59vWq1ZSzruVqHLU2fOTQjdhSsADYGqoGarnBbGC2IwJAVcRCPRIWQHvKFcFj1yvNjpvPe--S4u8Vcplmlx93kQHimieGR0KFEAOt6KcX6ENcU6jbVaqKOelHXKkve0qnmHMCOy3JzTJtJ4Knx9ymmtu0y62yH5-Mq5rBPJP_gqrA6R7Y1Ctv_2-abi7P98q_QEalsQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090941680</pqid></control><display><type>article</type><title>Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant</title><source>Wiley</source><creator>Sheu, Michael ; Molina Garcia, Sofia ; Shrivastava, Gautam ; Patel, Meera ; Mushtaq, Ali ; Crilley, Thomas ; Anwer, Faiz ; Majeed, Aneela</creator><creatorcontrib>Sheu, Michael ; Molina Garcia, Sofia ; Shrivastava, Gautam ; Patel, Meera ; Mushtaq, Ali ; Crilley, Thomas ; Anwer, Faiz ; Majeed, Aneela</creatorcontrib><description>Introduction
This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT).
Methods
This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
Results
Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
Conclusion
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures was low for detecting previously detected and new pathogens.</description><identifier>ISSN: 1398-2273</identifier><identifier>ISSN: 1399-3062</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.14345</identifier><identifier>PMID: 39012614</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Acute myeloid leukemia ; Adult ; Aged ; Allografts ; Bacteremia ; Bacteremia - diagnosis ; Bacteremia - etiology ; Bacteremia - microbiology ; Blood ; Blood Culture ; Cell culture ; Febrile Neutropenia - blood ; Febrile Neutropenia - microbiology ; Female ; hematopoietic stem cell transplant ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Humans ; infections ; Leukemia ; Leukemia, Myeloid, Acute - complications ; Leukemia, Myeloid, Acute - therapy ; Male ; Middle Aged ; Neutropenia ; Pathogens ; Retrospective Studies ; Stem cell transplantation ; Stem cells ; Transplantation, Homologous - adverse effects ; Transplants & implants ; Young Adult</subject><ispartof>Transplant infectious disease, 2024-08, Vol.26 (4), p.e14345-n/a</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Transplant Infectious Disease published by Wiley Periodicals LLC.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2435-4b88ccd484e580f2efee0fd2b72f4d0373f519eebd48fe39909e2624b10856bc3</cites><orcidid>0000-0002-6337-3408</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39012614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheu, Michael</creatorcontrib><creatorcontrib>Molina Garcia, Sofia</creatorcontrib><creatorcontrib>Shrivastava, Gautam</creatorcontrib><creatorcontrib>Patel, Meera</creatorcontrib><creatorcontrib>Mushtaq, Ali</creatorcontrib><creatorcontrib>Crilley, Thomas</creatorcontrib><creatorcontrib>Anwer, Faiz</creatorcontrib><creatorcontrib>Majeed, Aneela</creatorcontrib><title>Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>Introduction
This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT).
Methods
This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
Results
Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
Conclusion
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures was low for detecting previously detected and new pathogens.</description><subject>Acute myeloid leukemia</subject><subject>Adult</subject><subject>Aged</subject><subject>Allografts</subject><subject>Bacteremia</subject><subject>Bacteremia - diagnosis</subject><subject>Bacteremia - etiology</subject><subject>Bacteremia - microbiology</subject><subject>Blood</subject><subject>Blood Culture</subject><subject>Cell culture</subject><subject>Febrile Neutropenia - blood</subject><subject>Febrile Neutropenia - microbiology</subject><subject>Female</subject><subject>hematopoietic stem cell transplant</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>infections</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - complications</subject><subject>Leukemia, Myeloid, Acute - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutropenia</subject><subject>Pathogens</subject><subject>Retrospective Studies</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Transplantation, Homologous - adverse effects</subject><subject>Transplants & implants</subject><subject>Young Adult</subject><issn>1398-2273</issn><issn>1399-3062</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kbtuFTEQhlcIRC5Q8ALIEg0Um_i2F5cogRApUpqkoFr5Mk4cvPZie3V0Hoc3xTknpIjENB5L33wazd80Hwg-IbVOizMnhDPevWoOCROiZbinr3f92FI6sIPmKOcHjMkguHjbHDCBCe0JP2z-_HTgDYoWJVhAFqR8jAbp1Zc1QUYuIKnXAmjego_OIA_rL5idRIssDkLJaOPKPbKgkvOAAqwlxQVCJWQwSEldIO0GbPQ-bly4Q7I2dxDAaXQPsyxxiQ5K_eUCM9LgPSpJhrx4Gcq75o2VPsP7p_e4uf3-7ebsR3t1fXF59vWq1ZSzruVqHLU2fOTQjdhSsADYGqoGarnBbGC2IwJAVcRCPRIWQHvKFcFj1yvNjpvPe--S4u8Vcplmlx93kQHimieGR0KFEAOt6KcX6ENcU6jbVaqKOelHXKkve0qnmHMCOy3JzTJtJ4Knx9ymmtu0y62yH5-Mq5rBPJP_gqrA6R7Y1Ctv_2-abi7P98q_QEalsQ</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Sheu, Michael</creator><creator>Molina Garcia, Sofia</creator><creator>Shrivastava, Gautam</creator><creator>Patel, Meera</creator><creator>Mushtaq, Ali</creator><creator>Crilley, Thomas</creator><creator>Anwer, Faiz</creator><creator>Majeed, Aneela</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6337-3408</orcidid></search><sort><creationdate>202408</creationdate><title>Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant</title><author>Sheu, Michael ; Molina Garcia, Sofia ; Shrivastava, Gautam ; Patel, Meera ; Mushtaq, Ali ; Crilley, Thomas ; Anwer, Faiz ; Majeed, Aneela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2435-4b88ccd484e580f2efee0fd2b72f4d0373f519eebd48fe39909e2624b10856bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute myeloid leukemia</topic><topic>Adult</topic><topic>Aged</topic><topic>Allografts</topic><topic>Bacteremia</topic><topic>Bacteremia - diagnosis</topic><topic>Bacteremia - etiology</topic><topic>Bacteremia - microbiology</topic><topic>Blood</topic><topic>Blood Culture</topic><topic>Cell culture</topic><topic>Febrile Neutropenia - blood</topic><topic>Febrile Neutropenia - microbiology</topic><topic>Female</topic><topic>hematopoietic stem cell transplant</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>infections</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Acute - complications</topic><topic>Leukemia, Myeloid, Acute - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutropenia</topic><topic>Pathogens</topic><topic>Retrospective Studies</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Transplantation, Homologous - adverse effects</topic><topic>Transplants & implants</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheu, Michael</creatorcontrib><creatorcontrib>Molina Garcia, Sofia</creatorcontrib><creatorcontrib>Shrivastava, Gautam</creatorcontrib><creatorcontrib>Patel, Meera</creatorcontrib><creatorcontrib>Mushtaq, Ali</creatorcontrib><creatorcontrib>Crilley, Thomas</creatorcontrib><creatorcontrib>Anwer, Faiz</creatorcontrib><creatorcontrib>Majeed, Aneela</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley-Blackwell Open Access Backfiles (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheu, Michael</au><au>Molina Garcia, Sofia</au><au>Shrivastava, Gautam</au><au>Patel, Meera</au><au>Mushtaq, Ali</au><au>Crilley, Thomas</au><au>Anwer, Faiz</au><au>Majeed, Aneela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2024-08</date><risdate>2024</risdate><volume>26</volume><issue>4</issue><spage>e14345</spage><epage>n/a</epage><pages>e14345-n/a</pages><issn>1398-2273</issn><issn>1399-3062</issn><eissn>1399-3062</eissn><abstract>Introduction
This study explored the efficacy of repeat blood cultures in bacteremic acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem cell transplantation (HSCT).
Methods
This was a retrospective study of AML patients who experienced febrile neutropenia (FN) and bacteremia following HSCT at the Taussig Cancer Center from January 1, 2019, to December 31, 2022. The primary endpoint was the rate of positive repeat blood cultures following initial positive blood culture.
Results
Fifty patients were included in the study. There were 50 occurrences of FN with positive initial blood cultures that were diagnosed following HSCT. Fifty initial sets of blood cultures and 96 sets of repeat blood cultures were drawn between the 50 occurrences of FN. Twelve of 96 (12.5%) repeat blood culture sets were positive for a pathogen, which occurred over nine of 50 (18.0%) episodes of FN. Three of 96 (3.2%) repeat blood culture sets grew a pathogen that differed from the pathogen that grew in the preceding positive blood culture.
Conclusion
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures for detecting previously detected and new pathogens was low.
Among bacteremic AML patients in the post‐HSCT period, the yield of repeat blood cultures was low for detecting previously detected and new pathogens.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39012614</pmid><doi>10.1111/tid.14345</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6337-3408</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute myeloid leukemia Adult Aged Allografts Bacteremia Bacteremia - diagnosis Bacteremia - etiology Bacteremia - microbiology Blood Blood Culture Cell culture Febrile Neutropenia - blood Febrile Neutropenia - microbiology Female hematopoietic stem cell transplant Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans infections Leukemia Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - therapy Male Middle Aged Neutropenia Pathogens Retrospective Studies Stem cell transplantation Stem cells Transplantation, Homologous - adverse effects Transplants & implants Young Adult |
| title | Yield of repeat blood cultures in acute myeloid leukemia patients with febrile neutropenia and bacteremia following allogeneic hematopoietic stem cell transplant |
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