The safety and efficacy of adipose tissue-derived exosomes in treating mild to moderate plaque psoriasis: A clinical study

This study evaluates the safety and efficacy of autologous adipose-derived mesenchymal stem cell-derived exosomes as a treatment for Psoriasis, a chronic immune-related skin and joint disorder, compared to current treatments like topicals, phototherapy, and systemic. The study isolated exosomes from...

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Bibliographic Details
Published in:Life sciences (1973) 2024-09, Vol.353, p.122915, Article 122915
Main Authors: Mohseni Meybodi, Mohammad Ali, Nilforoushzadeh, Mohammad Ali, KhandanDezfully, Nooshin, Mansouri, Parvin
Format: Article
Language:English
Subjects:
Extracellular vesicles (EVs)
Mesenchymal Stem Cells (MSC)
Plaque psoriasis
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Summary:This study evaluates the safety and efficacy of autologous adipose-derived mesenchymal stem cell-derived exosomes as a treatment for Psoriasis, a chronic immune-related skin and joint disorder, compared to current treatments like topicals, phototherapy, and systemic. The study isolated exosomes from Mesenchymal Stem Cells(MSCs) of healthy adipose tissue using ultracentrifugation. 12 patients with plaque psoriasis were divided into three groups and given single doses of exosomes. Tissue samples were collected pre- and post-treatment and examined for inflammatory(TNFα, IL23, IL17, IFNγ, CD3) and anti-inflammatory (FOXP3, IL10) markers. The severity of the lesion was also evaluated. In this study, it was found that erythema and induration (P 
ISSN:0024-3205
1879-0631
1879-0631
DOI:10.1016/j.lfs.2024.122915