Residue‐Free Orally Administered Drug Carrier Based on a Porous Aromatic Framework for Efficient Multisite Treatment

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-11, Vol.20 (45), p.e2404643-n/a
• Main Authors: Xi, Enpeng, Zhao, Yun, Liu, Kangning, Ding, Qi, Yang, Fuming, Gao, Nan, Sun, Hanjun, Yuan, Ye, Zhu, Guangshan
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; combined therapy; Drug carriers; Drug Carriers - chemistry; Drug Liberation; Famotidine - administration & dosage; Famotidine - chemistry; Gastrointestinal system; Health services; Humans; Insulators; Intestine; Mesalamine - administration & dosage; Mesalamine - chemistry; Mesalamine - therapeutic use; Oral administration; oral drug carriers; Porosity; porous aromatic frameworks; Residues; response control release; targeted drug delivery; Vomiting
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202404643

Nowadays, oral medications are the primary method of treating disease due to their convenience, low cost, and safety, without the need for complex medical procedures. To maximize treatment effectiveness, almost all oral medications utilize drug carriers, such as capsules, liposomes, and sugar coatings. However, these carriers rely on dissolution or fragmentation to achieve drug release, which leads to drugs and carriers coabsorption in the body, causing unnecessary adverse drug reactions, such as nausea, vomiting, abdominal pain, and even death caused by allergy. Therefore, the ideal oral drug carrier should avoid degradation and absorption and be totally excreted after drug release at the desired location. Herein, a gastrointestinally stable oral drug carrier based on porous aromatic framework‐1 (PAF‐1) is constructed, and it is modified with famotidine (a well‐known gastric drug) and mesalazine (a well‐known ulcerative colitis drug) to verify the excellent potential of PAF‐1. The results demonstrate that PAF‐1 can accurately release famotidine in stomach, mesalazine in the intestine, and finally be completely excreted from the body without any residue after 12 h. The use of PAF materials for the construction of oral drug carriers with no residue in the gastrointestinal tract provides a new approach for efficient disease treatment. By rational design of porous aromatic frameworks, novel smart oral drug carriers are constructed that are stable in the whole digestive tract, do not remain in the body and can release different drugs in segmented response. It can improve the existing adverse drug reactions caused by the instability of drug carriers, that provide a new approach for efficient disease treatment.