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Hormonal male contraception
Introduction Male contraception with exogenously administered hormones suppresses both luteinizing hormone and follicle stimulating hormone leading to low intratesticular testosterone concentration. This results in reversible suppression of spermatogenesis and marked decrease in sperm output in the...
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| Published in: | Andrology (Oxford) 2024-10, Vol.12 (7), p.1551-1557 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 1557 |
| container_issue | 7 |
| container_start_page | 1551 |
| container_title | Andrology (Oxford) |
| container_volume | 12 |
| creator | Wang, Christina Meriggiola, Maria Cristina Behre, Hermann M. Page, Stephanie T. |
| description | Introduction
Male contraception with exogenously administered hormones suppresses both luteinizing hormone and follicle stimulating hormone leading to low intratesticular testosterone concentration. This results in reversible suppression of spermatogenesis and marked decrease in sperm output in the ejaculate and preventing pregnancy in the female partner.
Prior Studies
Studies of testosterone administered alone or in combination of another gonadotropin suppressive agent such as a progestin or gonadotropin releasing hormone (GnRH) analog showed decisively that the exogenous hormone administrations are effective in suppressing sperm output with few adverse events that are not anticipated. In contraceptive efficacy studies, testosterone alone or combined with a progestin are as effective in preventing pregnancies as female contraceptive methods.
Conclusion
Hormone combinations for male contraception are in late‐phase clinical trials and hold the promise of being the new, reversible contraception method for men in over half a century. Lessons learned from the male hormonal contraceptive development pave the way for new targeted approached to regulate male fertility. |
| doi_str_mv | 10.1111/andr.13699 |
| format | article |
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Male contraception with exogenously administered hormones suppresses both luteinizing hormone and follicle stimulating hormone leading to low intratesticular testosterone concentration. This results in reversible suppression of spermatogenesis and marked decrease in sperm output in the ejaculate and preventing pregnancy in the female partner.
Prior Studies
Studies of testosterone administered alone or in combination of another gonadotropin suppressive agent such as a progestin or gonadotropin releasing hormone (GnRH) analog showed decisively that the exogenous hormone administrations are effective in suppressing sperm output with few adverse events that are not anticipated. In contraceptive efficacy studies, testosterone alone or combined with a progestin are as effective in preventing pregnancies as female contraceptive methods.
Conclusion
Hormone combinations for male contraception are in late‐phase clinical trials and hold the promise of being the new, reversible contraception method for men in over half a century. Lessons learned from the male hormonal contraceptive development pave the way for new targeted approached to regulate male fertility.</description><identifier>ISSN: 2047-2919</identifier><identifier>ISSN: 2047-2927</identifier><identifier>EISSN: 2047-2927</identifier><identifier>DOI: 10.1111/andr.13699</identifier><identifier>PMID: 39016284</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Birth control ; Contraceptive Agents, Hormonal - administration & dosage ; Contraceptive Agents, Hormonal - adverse effects ; Contraceptive Agents, Male - administration & dosage ; Contraceptive Agents, Male - pharmacology ; Female ; gonadotropin releasing hormone analogs ; Hormonal Contraception ; Humans ; Male ; modified androgens ; progestin ; Progestins - administration & dosage ; Progestins - adverse effects ; Sperm ; Spermatogenesis - drug effects ; spermatogenesis suppression ; Testosterone</subject><ispartof>Andrology (Oxford), 2024-10, Vol.12 (7), p.1551-1557</ispartof><rights>2024 American Society of Andrology and European Academy of Andrology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2469-b05f2d498e264ccd3814d1e7b0a0a7a9089905d844c7d4630e82166b131fe6b83</cites><orcidid>0000-0003-0061-9834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39016284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Christina</creatorcontrib><creatorcontrib>Meriggiola, Maria Cristina</creatorcontrib><creatorcontrib>Behre, Hermann M.</creatorcontrib><creatorcontrib>Page, Stephanie T.</creatorcontrib><title>Hormonal male contraception</title><title>Andrology (Oxford)</title><addtitle>Andrology</addtitle><description>Introduction
Male contraception with exogenously administered hormones suppresses both luteinizing hormone and follicle stimulating hormone leading to low intratesticular testosterone concentration. This results in reversible suppression of spermatogenesis and marked decrease in sperm output in the ejaculate and preventing pregnancy in the female partner.
Prior Studies
Studies of testosterone administered alone or in combination of another gonadotropin suppressive agent such as a progestin or gonadotropin releasing hormone (GnRH) analog showed decisively that the exogenous hormone administrations are effective in suppressing sperm output with few adverse events that are not anticipated. In contraceptive efficacy studies, testosterone alone or combined with a progestin are as effective in preventing pregnancies as female contraceptive methods.
Conclusion
Hormone combinations for male contraception are in late‐phase clinical trials and hold the promise of being the new, reversible contraception method for men in over half a century. Lessons learned from the male hormonal contraceptive development pave the way for new targeted approached to regulate male fertility.</description><subject>Birth control</subject><subject>Contraceptive Agents, Hormonal - administration & dosage</subject><subject>Contraceptive Agents, Hormonal - adverse effects</subject><subject>Contraceptive Agents, Male - administration & dosage</subject><subject>Contraceptive Agents, Male - pharmacology</subject><subject>Female</subject><subject>gonadotropin releasing hormone analogs</subject><subject>Hormonal Contraception</subject><subject>Humans</subject><subject>Male</subject><subject>modified androgens</subject><subject>progestin</subject><subject>Progestins - administration & dosage</subject><subject>Progestins - adverse effects</subject><subject>Sperm</subject><subject>Spermatogenesis - drug effects</subject><subject>spermatogenesis suppression</subject><subject>Testosterone</subject><issn>2047-2919</issn><issn>2047-2927</issn><issn>2047-2927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp90EtLAzEUBeAgii21G7eCFNyIMDU3SfNYlvqEoiC6DplMBqbMTGrSQfrvTZ3ahQsvgZvFx-FyEDoHPIU0t6YtwhQoV-oIDQlmIiOKiOPDH9QAjWNc4TRy98gpGlCFgRPJhujiyYfGt6aeNKZ2E-vbTTDWrTeVb8_QSWnq6Mb7PUIfD_fvi6ds-fr4vJgvM0sYV1mOZyUpmJKOcGZtQSWwApzIscFGGIWlUnhWSMasKBin2EkCnOdAoXQ8l3SErvvcdfCfnYsb3VTRuro2rfNd1BRLEBJmFCd69YeufBfS-UkBllRQJlVSN72ywccYXKnXoWpM2GrAetea3rWmf1pL-HIf2eWNKw70t6MEoAdfVe22_0Tp-cvdWx_6DV84c58</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Wang, Christina</creator><creator>Meriggiola, Maria Cristina</creator><creator>Behre, Hermann M.</creator><creator>Page, Stephanie T.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0061-9834</orcidid></search><sort><creationdate>202410</creationdate><title>Hormonal male contraception</title><author>Wang, Christina ; Meriggiola, Maria Cristina ; Behre, Hermann M. ; Page, Stephanie T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2469-b05f2d498e264ccd3814d1e7b0a0a7a9089905d844c7d4630e82166b131fe6b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Birth control</topic><topic>Contraceptive Agents, Hormonal - administration & dosage</topic><topic>Contraceptive Agents, Hormonal - adverse effects</topic><topic>Contraceptive Agents, Male - administration & dosage</topic><topic>Contraceptive Agents, Male - pharmacology</topic><topic>Female</topic><topic>gonadotropin releasing hormone analogs</topic><topic>Hormonal Contraception</topic><topic>Humans</topic><topic>Male</topic><topic>modified androgens</topic><topic>progestin</topic><topic>Progestins - administration & dosage</topic><topic>Progestins - adverse effects</topic><topic>Sperm</topic><topic>Spermatogenesis - drug effects</topic><topic>spermatogenesis suppression</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Christina</creatorcontrib><creatorcontrib>Meriggiola, Maria Cristina</creatorcontrib><creatorcontrib>Behre, Hermann M.</creatorcontrib><creatorcontrib>Page, Stephanie T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Christina</au><au>Meriggiola, Maria Cristina</au><au>Behre, Hermann M.</au><au>Page, Stephanie T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hormonal male contraception</atitle><jtitle>Andrology (Oxford)</jtitle><addtitle>Andrology</addtitle><date>2024-10</date><risdate>2024</risdate><volume>12</volume><issue>7</issue><spage>1551</spage><epage>1557</epage><pages>1551-1557</pages><issn>2047-2919</issn><issn>2047-2927</issn><eissn>2047-2927</eissn><abstract>Introduction
Male contraception with exogenously administered hormones suppresses both luteinizing hormone and follicle stimulating hormone leading to low intratesticular testosterone concentration. This results in reversible suppression of spermatogenesis and marked decrease in sperm output in the ejaculate and preventing pregnancy in the female partner.
Prior Studies
Studies of testosterone administered alone or in combination of another gonadotropin suppressive agent such as a progestin or gonadotropin releasing hormone (GnRH) analog showed decisively that the exogenous hormone administrations are effective in suppressing sperm output with few adverse events that are not anticipated. In contraceptive efficacy studies, testosterone alone or combined with a progestin are as effective in preventing pregnancies as female contraceptive methods.
Conclusion
Hormone combinations for male contraception are in late‐phase clinical trials and hold the promise of being the new, reversible contraception method for men in over half a century. Lessons learned from the male hormonal contraceptive development pave the way for new targeted approached to regulate male fertility.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39016284</pmid><doi>10.1111/andr.13699</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0061-9834</orcidid></addata></record> |
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| ispartof | Andrology (Oxford), 2024-10, Vol.12 (7), p.1551-1557 |
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| source | Wiley |
| subjects | Birth control Contraceptive Agents, Hormonal - administration & dosage Contraceptive Agents, Hormonal - adverse effects Contraceptive Agents, Male - administration & dosage Contraceptive Agents, Male - pharmacology Female gonadotropin releasing hormone analogs Hormonal Contraception Humans Male modified androgens progestin Progestins - administration & dosage Progestins - adverse effects Sperm Spermatogenesis - drug effects spermatogenesis suppression Testosterone |
| title | Hormonal male contraception |
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