Quantitative calcium-based assessment of osteoporosis in dual-layer spectral CT

•Virtual calcium-only images (VCa) show good correlation with DEXA bone mineral density.•VCa might be used to estimate BMD as it is less prone to bone marrow changes.•A VCa cut-off of 126 HU can be used to identify abnormal bone mineral density. To evaluate a novel calcium-only imaging technique (VC...

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Bibliographic Details
Published in:European journal of radiology 2024-09, Vol.178, p.111606, Article 111606
Main Authors: Do, T.D., Rahn, S., Melzig, C., Heußel, C.P., Stiller, W., Kauczor, H.U., Weber, T.F., Skornitzke, S.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Aged
Bone Density
Calcium - metabolism
Calcium imaging
Computed tomography
Dual-layer detector
Female
Humans
Male
Middle Aged
Osteoporosis
Osteoporosis - diagnostic imaging
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
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Summary:•Virtual calcium-only images (VCa) show good correlation with DEXA bone mineral density.•VCa might be used to estimate BMD as it is less prone to bone marrow changes.•A VCa cut-off of 126 HU can be used to identify abnormal bone mineral density. To evaluate a novel calcium-only imaging technique (VCa) with subtracted bone marrow in osteoporosis in dual-layer CT (DLCT) compared to conventional CT images (CI) and dual-energy X-ray absorptiometry (DXA). Images of a multi-energy CT phantom with calcium inserts, quantitative CT calibration phantom, and of 55 patients (mean age: 64.6 ± 11.5 years) were acquired on a DLCT to evaluate bone mineral density (BMD). CI, calcium-suppressed images, and VCa were calculated. For investigating the association of VCa and CI with DXA a subsample of 30 patients (
ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2024.111606