Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of Ochna integerrima (Lour.) Merr

• Published in: Natural product research 2024-07, p.1-11
• Main Authors: Minh Nguyen, Hien, Nguyen, Khanh Phuc, Le, An Thuy Pham, Nguyen, Nguyen Huong Thi, Vu-Huynh, Long Kim, Le, Chi Kim Thi, Delpe Acharige, Anjana, Hull, Kenneth, Romo, Daniel
• Format: Article
• Language: English
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2024.2378195

This study explored, for the first time, the antioxidant (total antioxidant content, reducing power, ferric ion reducing antioxidant power, hydroxyl radical scavenging, ferrous ion-chelating assays), anti-tyrosinase, anti-inflammatory properties, and hepatoprotective effect in HepG2 cell lines of (Loureiro) Merrill flowers and seeds. All extracts except -hexane exhibited significant antioxidant activity, with high levels of tannin and proanthocyanidins. Luteolin ( ), 6- , -dimethylallylkaempferol7- - -d-glucopyranoside ( ), 6- , -dimethylallylquercetin7- - -d-glucopyranoside ( ), and 6- , -dimethylallyldihydrokaempferol 7- - -d-glucopyranoside ( ) were isolated using semi-preparative HPLC. Compounds - demonstrated good anti-tyrosinase activity. The most active hepatoprotective extracts were found to be aqueous extracts. The flower extracts exhibited greater anti-inflammatory properties by the decrease of NO in RAW 264.7 cells and bovine serum albumin protein. Among them, the -hexane and EtOAc extracts from flowers displayed promising anti-inflammatory activity. This was predicted by analysis of - . In summary, appears to be a promising natural source for antioxidant, anti-tyrosinase, and anti-inflammatory applications.