Rethinking Combination Therapy for S. aureus bacteremia: A Fading Paradigm

Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing b...

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Published in:The New microbiologica 2024-07, Vol.47 (2), p.183
Main Authors: Venturini, Sergio, Reffo, Ingrid, Avolio, Manuela, Basaglia, Giancarlo, Del Fabro, Giovanni, Callegari, Astrid, Bramuzzo, Igor, Tonizzo, Maurizio, Lucis, Riccardo, Pontoni, Elisa, De Santi, Laura, Crapis, Massimo
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Combined treatment
Daptomycin
Daptomycin - administration & dosage
Daptomycin - therapeutic use
Drug Therapy, Combination
Endocarditis
Female
Fosfomycin
Humans
Male
Middle Aged
Oxacillin
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
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Summary:Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans. Microbiologic clearance at the 72 hour mark demonstrates greater efficacy within the combination cohort (bacteremia persistence 29%) versus monotherapy (bacteremia persistence 78%). This limited case series suggests the potential superiority of combination therapy, prompting further investigations.
ISSN:1121-7138