Linalool-rich rosewood essential oil (Aniba rosaeodora Ducke) mitigates emotional and neurochemical impairments induced by ethanol binge-like exposure during adolescence in female rats

• Published in: Biomedicine & pharmacotherapy 2024-09, Vol.178, p.117120, Article 117120
• Main Authors: dos Santos, Éverton Renan Quaresma, Pantoja, Lucas Villar Pedrosa da Silva, Farias, Sarah Viana, Pinheiro, Bruno Gonçalves, Andrade, Eloisa Helena A., Mendes, Paulo Fernando Santos, Cruz, Jorddy Neves, Monteiro, Marta Chagas, Davis, Kelly, Lima, Rafael Rodrigues, Freitas, Jofre Jacob da Silva, Burbano, Rommel Mário Rodríguez, Prediger, Rui Daniel, Fontes-Junior, Enéas Andrade, Maia, José Guilherme S., Maia, Cristiane do Socorro Ferraz
• Format: Article
• Language: English
• Subjects: Adolescence; Aniba rosaeodora; Ethanol binge-drinking; Linalool; Neurobehavioral; Rosewood oil
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.117120

Linalool-rich Rosewood oil (Aniba rosaeodora Ducke) is a natural compound widely used in perfumery industry. Evidence suggests that linalool exerts antidepressant and anxiolytic effects. Conversely, ethanol binge drinking (i.e., intermittent and episodic consumption) during adolescence elicits neurobehavioral alterations associated with brain damage. Here, we investigated whether linalool-rich Rosewood oil administration can improve the emotional and molecular impairments associated with ethanol binge-like exposure during adolescence in female rats. Rosewood oil was obtained by hydrodistillation and posteriorly analyzed. Adolescent female Wistar rats received four-cycles of ethanol binge-like pattern (3 g/kg/day, 3 days on/4 days off) and daily Rosewood oil (35 mg/kg, intranasally) for 28 days. Twenty-four hours after treatments, it was evaluated the impact of ethanol exposure and Rosewood oil treatment on the putative emotional impairments assessed on the splash and forced swimming tests, as well as the levels of brain-derived neurotrophic factor (BDNF), S100B, oxidative parameters, and inflammatory cytokines in prefrontal cortex and hippocampus. Results indicated that Rosewood oil intranasal administration mitigated emotional impairments induced by ethanol exposure accompanied by a marked increase in BDNF, S100B, glutathione (GSH), and antioxidant activity equivalent to Trolox (TEAC) levels in brain areas. Rosewood oil treatment also prevented the ethanol-induced increase of interleukin-1β, interleukin-6, tumor necrosis factor α (TNF-α), and neurofilament light chain (NFL) levels. These findings provide the first evidence that Rosewood oil intranasal administration exerts protective effects against emotional and molecular impairments associated with adolescent ethanol binge-like exposure, possibly due to linalool actions triggering neurotrophic factors, rebalancing antioxidant status, and attenuating proinflammatory process.