Loading…

Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women

Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical nutrition (Edinburgh, Scotland) Scotland), 2024-09, Vol.43 (9), p.1929-1936
Main Authors:	Reynolds, Carmen J., Dyer, Roy B., Oberhelman-Eaton, Sara S., Konwinski, Brianna L., Weatherly, Renee M., Singh, Ravinder J., Thacher, Tom D.
Format:	Article
Language:	English
Subjects:	blood serum breast milk clinical nutrition Infant nutrition Lactation mass spectrometry metabolites milk Rickets skeletal development Supplementation
Citations:	Items that this one cites
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by
cites	cdi_FETCH-LOGICAL-c314t-72f6baae12fd68ae8e4a9e6635fcbb97442ebb74c29a3c86a7adaa4b6da4c3213
container_end_page	1936
container_issue	9
container_start_page	1929
container_title	Clinical nutrition (Edinburgh, Scotland)
container_volume	43
creator	Reynolds, Carmen J. Dyer, Roy B. Oberhelman-Eaton, Sara S. Konwinski, Brianna L. Weatherly, Renee M. Singh, Ravinder J. Thacher, Tom D.
description	Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D3-sulfate (VitD3-S) and 25-hydroxyvitamin D3-sulfate (25OHD3-S) for lactating women and assesses the response to high-dose VitD3 supplementation. Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD3 intake in 20 lactating women. Concentrations of VitD3-S and 25OHD3-S in milk, and 25OHD2, 25OHD3, 25OHD3-S, VitD3 and VitD3-S in serum were determined by mass spectrometry. Baseline vitamin D status was categorized as sufficient (mean ± SD serum 25OHD3 69 ± 19 nmol/L), and both serum VitD3 and 25OHD3 increased following supplementation (p
doi_str_mv	10.1016/j.clnu.2024.07.008
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3082628197</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0261561424002371</els_id><sourcerecordid>3153681699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-72f6baae12fd68ae8e4a9e6635fcbb97442ebb74c29a3c86a7adaa4b6da4c3213</originalsourceid><addsrcrecordid>eNqFkU9v1DAQxS1ERbeFL8AB-cglwX-ytiNxQW2hSJV6AM7W2JkgL06y2E4R376OtnCE03g0v_dkvUfIa85azrh6d2h9nNdWMNG1TLeMmWdkx_dSNLw38jnZMaF4s1e8OycXOR8YY3upzQtyLvuq0VrsyPhljSMUHOhDKDCFmV7TCQu4JYaCmSY8Jsw4F3pMSz1vr7TEeqloxrROFOZhW1xCyGUK8QddRhrBFyhh_k5_LRPOL8nZCDHjq6d5Sb59vPl6ddvc3X_6fPXhrvGSd6XRYlQOALkYB2UADXbQo1JyP3rnet11Ap3TnRc9SG8UaBgAOqcG6LwUXF6Styff-tufK-Zip5A9xggzLmu2ssajDFd9_3-UGaGE4b2uqDihPi05JxztMYUJ0m_Lmd2qsAe7VWG3KizTtlZRRW-e_Fc34fBX8if7Crw_AVgDeQiYbPYBZ49DSOiLHZbwL_9Hfjqciw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3082628197</pqid></control><display><type>article</type><title>Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women</title><source>ScienceDirect Freedom Collection</source><creator>Reynolds, Carmen J. ; Dyer, Roy B. ; Oberhelman-Eaton, Sara S. ; Konwinski, Brianna L. ; Weatherly, Renee M. ; Singh, Ravinder J. ; Thacher, Tom D.</creator><creatorcontrib>Reynolds, Carmen J. ; Dyer, Roy B. ; Oberhelman-Eaton, Sara S. ; Konwinski, Brianna L. ; Weatherly, Renee M. ; Singh, Ravinder J. ; Thacher, Tom D.</creatorcontrib><description>Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D3-sulfate (VitD3-S) and 25-hydroxyvitamin D3-sulfate (25OHD3-S) for lactating women and assesses the response to high-dose VitD3 supplementation. Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD3 intake in 20 lactating women. Concentrations of VitD3-S and 25OHD3-S in milk, and 25OHD2, 25OHD3, 25OHD3-S, VitD3 and VitD3-S in serum were determined by mass spectrometry. Baseline vitamin D status was categorized as sufficient (mean ± SD serum 25OHD3 69 ± 19 nmol/L), and both serum VitD3 and 25OHD3 increased following supplementation (p < 0.001). 25OHD3-S was 91 ± 19 nmol/L in serum and 0.47 ± 0.09 nmol/L in breastmilk. VitD3-S concentrations were 2.92 ± 0.70 nmol/L in serum and 6.4 ± 3.9 nmol/L in breastmilk. Neither sulfated metabolite significantly changed with supplementation in either serum or breastmilk. Sulfated vitamin D metabolites have prominent roles for women during lactation with 25OHD3-S highly abundant in serum and VitD3-S distinctly abundant in breastmilk. These data support the notion that 25OHD3-S and VitD3-S may have physiological relevance during lactation and nutritional usage for nursing infants.</description><identifier>ISSN: 0261-5614</identifier><identifier>ISSN: 1532-1983</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2024.07.008</identifier><identifier>PMID: 39024772</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>blood serum ; breast milk ; clinical nutrition ; Infant nutrition ; Lactation ; mass spectrometry ; metabolites ; milk ; Rickets ; skeletal development ; Supplementation</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2024-09, Vol.43 (9), p.1929-1936</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c314t-72f6baae12fd68ae8e4a9e6635fcbb97442ebb74c29a3c86a7adaa4b6da4c3213</cites><orcidid>0000-0002-4372-6122</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39024772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reynolds, Carmen J.</creatorcontrib><creatorcontrib>Dyer, Roy B.</creatorcontrib><creatorcontrib>Oberhelman-Eaton, Sara S.</creatorcontrib><creatorcontrib>Konwinski, Brianna L.</creatorcontrib><creatorcontrib>Weatherly, Renee M.</creatorcontrib><creatorcontrib>Singh, Ravinder J.</creatorcontrib><creatorcontrib>Thacher, Tom D.</creatorcontrib><title>Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D3-sulfate (VitD3-S) and 25-hydroxyvitamin D3-sulfate (25OHD3-S) for lactating women and assesses the response to high-dose VitD3 supplementation. Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD3 intake in 20 lactating women. Concentrations of VitD3-S and 25OHD3-S in milk, and 25OHD2, 25OHD3, 25OHD3-S, VitD3 and VitD3-S in serum were determined by mass spectrometry. Baseline vitamin D status was categorized as sufficient (mean ± SD serum 25OHD3 69 ± 19 nmol/L), and both serum VitD3 and 25OHD3 increased following supplementation (p < 0.001). 25OHD3-S was 91 ± 19 nmol/L in serum and 0.47 ± 0.09 nmol/L in breastmilk. VitD3-S concentrations were 2.92 ± 0.70 nmol/L in serum and 6.4 ± 3.9 nmol/L in breastmilk. Neither sulfated metabolite significantly changed with supplementation in either serum or breastmilk. Sulfated vitamin D metabolites have prominent roles for women during lactation with 25OHD3-S highly abundant in serum and VitD3-S distinctly abundant in breastmilk. These data support the notion that 25OHD3-S and VitD3-S may have physiological relevance during lactation and nutritional usage for nursing infants.</description><subject>blood serum</subject><subject>breast milk</subject><subject>clinical nutrition</subject><subject>Infant nutrition</subject><subject>Lactation</subject><subject>mass spectrometry</subject><subject>metabolites</subject><subject>milk</subject><subject>Rickets</subject><subject>skeletal development</subject><subject>Supplementation</subject><issn>0261-5614</issn><issn>1532-1983</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxS1ERbeFL8AB-cglwX-ytiNxQW2hSJV6AM7W2JkgL06y2E4R376OtnCE03g0v_dkvUfIa85azrh6d2h9nNdWMNG1TLeMmWdkx_dSNLw38jnZMaF4s1e8OycXOR8YY3upzQtyLvuq0VrsyPhljSMUHOhDKDCFmV7TCQu4JYaCmSY8Jsw4F3pMSz1vr7TEeqloxrROFOZhW1xCyGUK8QddRhrBFyhh_k5_LRPOL8nZCDHjq6d5Sb59vPl6ddvc3X_6fPXhrvGSd6XRYlQOALkYB2UADXbQo1JyP3rnet11Ap3TnRc9SG8UaBgAOqcG6LwUXF6Styff-tufK-Zip5A9xggzLmu2ssajDFd9_3-UGaGE4b2uqDihPi05JxztMYUJ0m_Lmd2qsAe7VWG3KizTtlZRRW-e_Fc34fBX8if7Crw_AVgDeQiYbPYBZ49DSOiLHZbwL_9Hfjqciw</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Reynolds, Carmen J.</creator><creator>Dyer, Roy B.</creator><creator>Oberhelman-Eaton, Sara S.</creator><creator>Konwinski, Brianna L.</creator><creator>Weatherly, Renee M.</creator><creator>Singh, Ravinder J.</creator><creator>Thacher, Tom D.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-4372-6122</orcidid></search><sort><creationdate>20240901</creationdate><title>Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women</title><author>Reynolds, Carmen J. ; Dyer, Roy B. ; Oberhelman-Eaton, Sara S. ; Konwinski, Brianna L. ; Weatherly, Renee M. ; Singh, Ravinder J. ; Thacher, Tom D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-72f6baae12fd68ae8e4a9e6635fcbb97442ebb74c29a3c86a7adaa4b6da4c3213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>blood serum</topic><topic>breast milk</topic><topic>clinical nutrition</topic><topic>Infant nutrition</topic><topic>Lactation</topic><topic>mass spectrometry</topic><topic>metabolites</topic><topic>milk</topic><topic>Rickets</topic><topic>skeletal development</topic><topic>Supplementation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reynolds, Carmen J.</creatorcontrib><creatorcontrib>Dyer, Roy B.</creatorcontrib><creatorcontrib>Oberhelman-Eaton, Sara S.</creatorcontrib><creatorcontrib>Konwinski, Brianna L.</creatorcontrib><creatorcontrib>Weatherly, Renee M.</creatorcontrib><creatorcontrib>Singh, Ravinder J.</creatorcontrib><creatorcontrib>Thacher, Tom D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reynolds, Carmen J.</au><au>Dyer, Roy B.</au><au>Oberhelman-Eaton, Sara S.</au><au>Konwinski, Brianna L.</au><au>Weatherly, Renee M.</au><au>Singh, Ravinder J.</au><au>Thacher, Tom D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>43</volume><issue>9</issue><spage>1929</spage><epage>1936</epage><pages>1929-1936</pages><issn>0261-5614</issn><issn>1532-1983</issn><eissn>1532-1983</eissn><abstract>Concentrations of vitamin D (VitD) and 25-hydroxyvitamin D (25OHD) in breastmilk are low despite the essential role of VitD for normal infant bone development, yet additional metabolic forms of vitamin D may be present. This study evaluates the contribution of sulfated vitamin D metabolites, vitamin D3-sulfate (VitD3-S) and 25-hydroxyvitamin D3-sulfate (25OHD3-S) for lactating women and assesses the response to high-dose VitD3 supplementation. Serum and breastmilk were measured before and after 28 days with 5000 IU/day VitD3 intake in 20 lactating women. Concentrations of VitD3-S and 25OHD3-S in milk, and 25OHD2, 25OHD3, 25OHD3-S, VitD3 and VitD3-S in serum were determined by mass spectrometry. Baseline vitamin D status was categorized as sufficient (mean ± SD serum 25OHD3 69 ± 19 nmol/L), and both serum VitD3 and 25OHD3 increased following supplementation (p < 0.001). 25OHD3-S was 91 ± 19 nmol/L in serum and 0.47 ± 0.09 nmol/L in breastmilk. VitD3-S concentrations were 2.92 ± 0.70 nmol/L in serum and 6.4 ± 3.9 nmol/L in breastmilk. Neither sulfated metabolite significantly changed with supplementation in either serum or breastmilk. Sulfated vitamin D metabolites have prominent roles for women during lactation with 25OHD3-S highly abundant in serum and VitD3-S distinctly abundant in breastmilk. These data support the notion that 25OHD3-S and VitD3-S may have physiological relevance during lactation and nutritional usage for nursing infants.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39024772</pmid><doi>10.1016/j.clnu.2024.07.008</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4372-6122</orcidid><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0261-5614
ispartof	Clinical nutrition (Edinburgh, Scotland), 2024-09, Vol.43 (9), p.1929-1936
issn	0261-5614 1532-1983 1532-1983
language	eng
recordid	cdi_proquest_miscellaneous_3082628197
source	ScienceDirect Freedom Collection
subjects	blood serum breast milk clinical nutrition Infant nutrition Lactation mass spectrometry metabolites milk Rickets skeletal development Supplementation
title	Sulfated vitamin D metabolites represent prominent roles in serum and in breastmilk of lactating women
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T11%3A41%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sulfated%20vitamin%20D%20metabolites%20represent%20prominent%20roles%20in%20serum%20and%20in%20breastmilk%20of%20lactating%20women&rft.jtitle=Clinical%20nutrition%20(Edinburgh,%20Scotland)&rft.au=Reynolds,%20Carmen%20J.&rft.date=2024-09-01&rft.volume=43&rft.issue=9&rft.spage=1929&rft.epage=1936&rft.pages=1929-1936&rft.issn=0261-5614&rft.eissn=1532-1983&rft_id=info:doi/10.1016/j.clnu.2024.07.008&rft_dat=%3Cproquest_cross%3E3153681699%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c314t-72f6baae12fd68ae8e4a9e6635fcbb97442ebb74c29a3c86a7adaa4b6da4c3213%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3082628197&rft_id=info:pmid/39024772&rfr_iscdi=true