Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans

[Display omitted] Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that L...

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Bibliographic Details
Published in:Neuroscience letters 2024-08, Vol.837, p.137903, Article 137903
Main Authors: Ornelas, Isis M., Carrilho, Beatriz de S., Ventura, Matheus Antonio V. de C., Domith, Ivan, de V. Silveira, Christiane M., dos Santos, Vanessa F., Delou, João M., Moll, Francisco, Pereira, Henrique Marcelo G., Junqueira, Magno, Aguilaniu, Hugo, Rehen, Stevens
Format: Article
Language:English
Subjects:
C. elegans
Locomotion
Lysergic acid diethylamide
Psychedelics
SER-4 receptor
Serotonin
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Summary:[Display omitted] Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD’s effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.
ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/j.neulet.2024.137903