Neurological insights into brain-targeted cancer therapy and bioinspired microrobots

• Published in: Drug discovery today 2024-09, Vol.29 (9), p.104105, Article 104105
• Main Authors: Ghosh, Shampa, Bhaskar, Rakesh, Mishra, Richa, Arockia Babu, M., Abomughaid, Mosleh Mohammad, Jha, Niraj Kumar, Sinha, Jitendra Kumar
• Format: Article
• Language: English
• Subjects: artificial intelligence; blood–brain barrier; brain-targeted cancer therapy; drug delivery; drug discovery; immunotherapy; neuro-oncology; patient-centred care; precision medicine
• ISSN: 1359-6446; 1878-5832; 1878-5832
• DOI: 10.1016/j.drudis.2024.104105

•Bioinspired microrobots offer innovative solutions for brain-targeted cancer therapy.•These microrobots navigate the blood–brain barrier for precise drug delivery.•Interdisciplinary collaboration enhances the efficacy of microrobot applications.•Recent advancements have shown promise in improving brain cancer treatment outcomes.•Ethical and biocompatibility considerations are crucial for clinical application. Cancer, a multifaceted and pernicious disease, continuously challenges medicine, requiring innovative treatments. Brain cancers pose unique and daunting challenges due to the intricacies of the central nervous system and the blood–brain barrier. In this era of precision medicine, the convergence of neurology, oncology, and cutting-edge technology has given birth to a promising avenue – targeted cancer therapy. Furthermore, bioinspired microrobots have emerged as an ingenious approach to drug delivery, enabling precision and control in cancer treatment. This Keynote review explores the intricate web of neurological insights into brain-targeted cancer therapy and the paradigm-shifting world of bioinspired microrobots. It serves as a critical and comprehensive overview of these evolving fields, aiming to underscore their integration and potential for revolutionary cancer treatments.