Microscopic photoplethysmography-based evaluation of cardiotoxicity in whitefish larvae induced by acute exposure to cadmium and phenol

Toxic environmental pollutants pose a health risk for both humans and animals. Accumulation of industrial contaminants in freshwater fish may become a significant threat to biodiversity. Comprehensive monitoring of the impact of environmental stressors on fish functional systems is important and use...

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Bibliographic Details
Published in:Journal of biophotonics 2024-09, Vol.17 (9), p.e202400111
Main Authors: Machikhin, Alexander, Guryleva, Anastasia, Chakraborty, Anirban, Khokhlov, Demid, Selyukov, Alexander, Shuman, Leonid, Bukova, Valeriya, Efremova, Ekaterina, Rudenko, Ekaterina, Burlakov, Alexander
Format: Article
Language:English
Subjects:
Abnormalities
Aquatic organisms
Atria
Bioaccumulation
Biocompatibility
Biodiversity
Cadmium
Cardiotoxicity
Chemical activity
Circulatory system
Contaminants
Coregonus nasus
Environmental effects
Environmental impact
Environmental monitoring
Environmental stress
Exposure
External stimuli
Fish
Freshwater fish
Health risks
In vivo methods and tests
Industrial pollution
Larvae
Phenols
Pollutants
Pollution effects
Toxicants
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Summary:Toxic environmental pollutants pose a health risk for both humans and animals. Accumulation of industrial contaminants in freshwater fish may become a significant threat to biodiversity. Comprehensive monitoring of the impact of environmental stressors on fish functional systems is important and use of non-invasive tools that can detect the presence of these toxicants in vivo is desirable. The blood circulatory system, by virtue of its sensitivity to the external stimuli, could be an informative indicator of chemical exposure. In this study, microscopic photoplethysmography-based approach was used to investigate the cardiac activity in broad whitefish larvae (Coregonus nasus) under acute exposure to cadmium and phenol. We identified contamination-induced abnormalities in the rhythms of the ventricle and atrium. Our results allow introducing additional endpoints to evaluate the cardiac dysfunction in fish larvae and contribute to the non-invasive evaluation of the toxic effects of industrial pollutants on bioaccumulation and aquatic life.
ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.202400111